Glucagon-like peptide-1 (GLP-1) based therapy is well established for treating diabetes mellitus type 2. Moreover, GLP-1 receptor agonists influence weight loss, and have potential for treating obesity. GLP-1 receptor agonists should be administered in low doses, together with drugs that potentiate insulin release, to avoid some minor side effects. We have focused on incretin hormones, especially GLP-1 and its analogues. Here we discuss the effect of the third intracellular loop-derived peptide of GLP-1 receptor on intracellular mono-ADP-ribosyltransferase and its role in regulating the receptor. We suggest that this intracellular mono-ADP-ribosyltransferase could constitute a possible novel pharmacological target in the treatment of diabetes mellitus type 2 and obesity.

Rights

URN

URN:NBN:SI:doc-ZHWSLL59

COBISSID

30773209

Added

17.11.2014

Metadata

Citation

APA:

Bavec, Aljoša (2013). Mono-ADP-ribosyltransferase as a potential pharmacological drug target in the GLP-1 based therapy of obesity and diabetes mellitus type 2. Acta chimica slovenica, volume 60, issue 2, str. 237-242. URN:NBN:SI:doc-ZHWSLL59 from http://www.dlib.si

MLA:

Bavec, Aljoša. "Mono-ADP-ribosyltransferase as a potential pharmacological drug target in the GLP-1 based therapy of obesity and diabetes mellitus type 2." Acta chimica slovenica volume 60. issue 2 (2013) str. 237-242.
<http://www.dlib.si/?URN=URN:NBN:SI:doc-ZHWSLL59>

Acta chimica slovenica
1993-
(Assembly record)