{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-9LGBPAFC/d3185a9b-127a-44a4-87e5-b63ba3bfb8bf/PDF","dcterms:extent":"377 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-9LGBPAFC/6607dd24-abde-4a7f-96df-940d36f6e054/TEXT","dcterms:extent":"32 KB"}],"edm:TimeSpan":{"@rdf:about":"1998-2025","edm:begin":{"@xml:lang":"en","#text":"1998"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-9LGBPAFC","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-KC6O72BG"},{"@xml:lang":"sl","#text":"Acta chimica slovenica"}],"dcterms:issued":"2015","dc:creator":["Bukovec, Polona","Meden, Anton","Smrkolj, Matej","Vrečer, Franc"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:62"},{"@xml:lang":"sl","#text":"str. 958-966"}],"dc:identifier":["ISSN:1318-0207","COBISSID:4013681","URN:URN:NBN:SI:doc-9LGBPAFC"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"dc:subject":[{"@xml:lang":"en","#text":"atomic force microscope"},{"@xml:lang":"en","#text":"crystal habit"},{"@xml:lang":"en","#text":"dissolution rate"},{"@xml:lang":"sl","#text":"farmacevtske oblike"},{"@xml:lang":"sl","#text":"fizikalne lastnosti"},{"@xml:lang":"sl","#text":"kemijske lastnosti"},{"@xml:lang":"sl","#text":"simvastatin"},{"@xml:lang":"en","#text":"single crystal orientation"},{"@xml:lang":"sl","#text":"zdravilne učinkovine"}],"dcterms:temporal":{"@rdf:resource":"1998-2025"},"dc:title":{"@xml:lang":"sl","#text":"Influence of crystal habit on the dissolution of simvastatin single crystals|"},"dc:description":[{"@xml:lang":"sl","#text":"In order to achieve better in-vivo performance of the final dosage form comprising a poorly soluble drug the physicochemical properties of the active pharmaceutical ingredient can be altered not only by changing the solid state form but also through the conversion of their crystal habits. To elucidate this approach in the case of simvastatin, the dissolution behaviour of large crystals with the same internal structure but expressing different crystal habits was studied using atomic force microscope. The obtained differences in the dissolution were explained through the determination of crystal morphology, its orientation and assignation of the molecular functional groups that were emerging on the surface of the dissolving crystal face. The dissolution rates of the particular crystal faces measured in situ by atomic force microscopy were found to be distinctly higher than others. The dissolution rate of single crystals differed as a consequence of higher incidence of more polar crystal faces in case of rod shaped crystals isolated from more hydrophilic solvent mixture which we have established through a thorough research of the single crystal morphology, orientation and the assignation of specific functional groups for each of evolved crystal faces"},{"@xml:lang":"sl","#text":"Izboljšane in-vivo lastnosti končne farmacevtske oblike, ki vsebuje slabo topno zdravilno učinkovino, lahko dosežemo s spreminjanjem fizikalno-kemijskih lastnosti zdravilne učinkovine, ne samo v smislu prilagajanja notranje strukture, temveč tudi preko spremembe kristalnega habitusa. Za pojasnitev tega pristopa smo, na primeru simvastatina, z mikroskopom na atomsko silo spremljali hitrost raztapljanja izoliranih večjih monokristalov, ki so imeli enako notranjo strukturo in so se razlikovali po zunanji obliki kristala. Hitrost raztapljanja določenih kristalnih ploskev je bila bistveno hitrejša glede na ostale. Razlika v hitrosti raztapljanja izoliranih monokristalov je bila posledica večje pojavnosti bolj polarnih kristalnih ploskev v primeru paličastih kristalov, ki smo jih izolirali iz polarnih topil, kar smo ugotovili na osnovi poglobljene raziskave morfoloških lastnosti, orientacije monokristalov in asignacije specifičnih funkcionalnih skupin za vsako izmed izraženih kristalnih ploskev"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-9LGBPAFC","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-9LGBPAFC"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-9LGBPAFC/d3185a9b-127a-44a4-87e5-b63ba3bfb8bf/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-9LGBPAFC/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-9LGBPAFC"}}}}