{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-ICVFQ0GY/464d85a2-8956-4e81-9a42-5f814fb186fa/PDF","dcterms:extent":"278 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-ICVFQ0GY/ca199e91-754f-4997-bdc5-e5da710412ff/TEXT","dcterms:extent":"23 KB"}],"edm:TimeSpan":{"@rdf:about":"2022-2025","edm:begin":{"@xml:lang":"en","#text":"2022"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-ICVFQ0GY","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-UCB4A42Q"},{"@xml:lang":"sl","#text":"Placebo"}],"dcterms:issued":"2024","dc:creator":["Kovšca, Živa","Šenica, Ana"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"str. 34-37"}],"dc:identifier":["COBISSID_HOST:208893955","ISSN:2820-5014","URN:URN:NBN:SI:doc-ICVFQ0GY"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Fakulteta za farmacijo, ŠSSFD"},"dc:subject":[{"@xml:lang":"sl","#text":"amiloidogeni proteini"},{"@xml:lang":"sl","#text":"aptamer"},{"@xml:lang":"sl","#text":"Nevrodegenerativne bolezni"},{"@xml:lang":"sl","#text":"SELEX"}],"dcterms:temporal":{"@rdf:resource":"2022-2025"},"dc:title":{"@xml:lang":"sl","#text":"Amiloidogeni proteini kot tarča aptamerov|"},"dc:description":[{"@xml:lang":"sl","#text":"Neurodegenerative diseases are becoming an increasingly significant global issue. They are often associated with the misfolding of amyloidogenic proteins which can aggregate and accumulate in various regions of the central nervous system. The pathology of these diseases is still largely unexplored. Aptamers are short nucleic acids with a function similar to classical antibodies but with many advantages over them. They represent a new tool in understanding the pathophysiology of neurodegenerative diseases. Aptamers also exhibit the potential to be used as therapeutics, as there are few effective treatments which could prevent the development of the disease or at least prevent the disease progression. Early detection of neurodegenerative diseases is important since the disease may be present before the onset of clinical symptoms. Aptamers are highly useful for detecting pathological proteins as they are capable of detecting specific neurotoxic conformations at low concentrations"},{"@xml:lang":"sl","#text":"Nevrodegenerativne bolezni predstavljajo vse večji svetovni problem. Pogosto jih povezujemo z nepravilnim zvijanjem amiloidogenih proteinov, ki se nato agregirajo in akumulirajo v različnih predelih centralnega živčnega sistema. Patologija bolezni je v veliki meri še neraziskano področje. Aptameri so kratke nukleinske kisline s podobno funkcijo kot klasična protitelesa, a hkrati s številnimi prednosti pred klasičnimi protitelesi. Predstavljajo novo orodje pri razumevanju patofiziologije nevrodegenerativnih bolezni. Uporabni bi lahko bili tudi kot terapevtiki, saj za velik del nevrodegenerativnih bolezni še ni učinkovite terapije, ki bi proces nastanka bolezni preprečila ali pa vsaj omejila. Pomembno je tudi zgodnje odkrivanje nevrodegenerativnih bolezni, saj je bolezen lahko prisotna že pred pojavitvijo kliničnih znakov. Aptameri so zelo uporabni tudi za detekcijo patoloških proteinov, saj so sposobni zaznati specifične nevrotoksične konformacije v nizkih koncentracijah"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-ICVFQ0GY","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-ICVFQ0GY"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-ICVFQ0GY/464d85a2-8956-4e81-9a42-5f814fb186fa/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:dataProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-ICVFQ0GY/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-ICVFQ0GY"}}}}