{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-O2IYGWJ3/4a035ea5-5d94-4612-a9fc-228adb894dfb/PDF","dcterms:extent":"92 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-O2IYGWJ3/c49a9eeb-b32b-4655-8392-9541f21e1fb2/TEXT","dcterms:extent":"18 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-O2IYGWJ3","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2003","dc:creator":["Sojar, Valentin","Stanisavljević, Dragoje","Tomažič, Aleš","Trotovšek, Blaž"],"dc:format":{"@xml:lang":"sl","#text":"str. I-37-I-39"},"dc:identifier":["ISSN:1318-0347","COBISSID_HOST:16592089","URN:URN:NBN:SI:doc-O2IYGWJ3"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"Diagnosis"},{"@xml:lang":"sl","#text":"Gallbladder Neoplasms"},{"@xml:lang":"sl","#text":"Neoplasm Staging"},{"@xml:lang":"sl","#text":"Novotvorba, stadij"},{"@xml:lang":"sl","#text":"Surgery"},{"@xml:lang":"sl","#text":"Treatment Outcome"},{"@xml:lang":"sl","#text":"Zdravljenje, izid"},{"@xml:lang":"sl","#text":"Žolčnik, novotvorbe"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Rak žolčnika| Gallbladder carcinoma|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Carcinoma of the gallbladder is a tumour with a dismal prognosis and 5 years overall survival rate less than 5%. Among the tumours of the gastrointestinal tract it is fifth in the row and its incidence is approximately 1.2/105. Tumour occurs more often (2-6 times) in women and in people over 50 years old (90%). According to the Slovenian Registry of Cancer fory ear 1998 the incidence of gallbladder carcinoma was 2.7/105 and it occurred 4 times more often among women. The most important risk factors for development of gallbladder carcinoma are: bile stones, chronic inflammation and polyps of the gallbladder. Carcinoma of the gallbladder develops in only 2-3% of the patients with bile stones. When discovered, carcinoma has already invaded the liver in 60%, regional lymph nodes in 45% and the other surrounding organs in 40%. Carcinoma is at time of diagnosis already disseminated in distant organs in 20%. Only in 10% of the patients it is confined to the gallbladder wall. Before the routine use of the ultrasound, computed tomography and tumour markers the disease was discovered preoperatively in 10% versus 90% today. Diagnostic percutaneous biopsy is not recommended. TNM classification and staging of the disease is important for the decision of the modality of treatment. Conclusions. For TNM stage I gallbladder carcinoma, simple cholecystectomy is sufficient When stage II-Na is discovered, \"en block\" resection of gallbladder, liver segments 4b and 5, common bile duct and thorough lymphadenectomy is recommended. Regional radiotherapy and intraarterial chemotherapy with Mitomycin-C are showing promising results. Longterm outcome in patients with gallbladder carcinoma is improving but it is still disappointing"},{"@xml:lang":"sl","#text":"Izhodišča. Rak žolčnika je tumor s slabo prognozo. Opisano 5-letno prežive je je večinoma pod 5%. Je peti najpogostejši tumor prebavne cevi (1.2/105). Tumorje pogostejši pri ženskah (2-6:1) in starejših od 50 let (90%). Po podatkih Registra raka R Slovenije za leto 1998 je bila incidenca v Sloveniji 2,7/105 in razmerje med ženskami in moškmi 4:1 Med pogostejše dejavnike tveganja prištevamo žolčne kamne, kronično vnetje žolčnika in polipe žolčnika.Karcinom se pojavi le pri 2-3% bolnikov z žolčnimi kamni. Ob odkritjubolezni je rak že razširjen v jetra (60%), področne bezgavke (45%), druge organe v bližini (40%). Zasevke v drugih organih odkrijemo pri 20% bolnikov, le pri desetini bolnikov je bolezen omejena na steno žolčnika. Pred rutinsko uporabo ultrazvoka, CT in tumorskih markerjev je bila bolezen pred operacijo odkrita le v 20%. Danes jo odkrijemo v 90%. Z ozirom na velikost tumorja, prizadetost bezgavk in odda jene zasevke bolnike razvrstimo v stadijebolezni po klasifikaciji TNM. Zaključki. Za uspešno zdravljenje raka žolčnika stadija I zadošča odstranitev žolčnika, za stadij II-IVa je nujna resekcija 4b in 5. segmenta jeter, resekcija skupnega žolčevoda ter odstranitev bezgavk. Regionalna radioterapija in intraarterijska kemoterapija z mitomycinom sta pokazali obetavne rezultate. Rezultati zdravljenja napredovalega karcinoma žolčnika so slabi"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-O2IYGWJ3","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-O2IYGWJ3"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-O2IYGWJ3/4a035ea5-5d94-4612-a9fc-228adb894dfb/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-O2IYGWJ3/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-O2IYGWJ3"}}}}