137 KB50 KB199420252003Avberšek, AndrejaRečnik, Gregorštevilka:1letnik:42str. 3-16ISSN:0025-8121COBISSID:16438745URN:URN:NBN:SI:doc-QZERZ8AVslMedicinski razglediMedicinski razglediActivities Of Daily LivinganketeBolečinabolnikiDepresijaDepressionDiagnosisDnevne aktivnostiDrug TherapygibanjeGibanje, motnjeKvaliteta življenjamotnjeMovement DisordersNeurologic ExaminationNevrološka preiskavaPainParkinson DiseaseParkinsonova bolezenQuality Of LifeQuestionnairesKako izboljšati kvaliteto življenja pri bolnikih s parkinsonizmom?| How to improve the quality of life of people with Parkinsonism?|Parkinsonism is a chronic disorder of the central nervous system characterizedpathologically by degeneration of dopamine neurons in substantia nigra pars compacta. Consequently, striatal dopamine levels decrease resultingin classical motor signs (tremor, rigidity, akinesia, postural impairment). Recently, pathological changes have been described also in limbicand prefrontal cortices which may explain non-motor parkinsonian symptoms (dementia, depression). As yet there has been no study in Slovenia onhow various factors influence quality of life (QoL) in Parkinsonian patients. 71 patients were asked to assess quality of their life on a visual analogue scale and with EQ-5D instrument. According to the results on the VAS they were divided into two groups. The following parameters were studied in all patients: motor disability, impairment in daily activities, cognitive abilities, depression and self-assessment of their health state. Depression was assessed in carers. Our results show that depression and impairment in daily activities, but not motor or cognitive disability, influence, QoL in patients with parkinsonism. We propose that clinical examination of the patients includes not only motor assessment but also assessment of mood in patients and occasionally carers. Improvement in daily activities can be reached with a multidisciplinary team management of the patientPatomorfološka osnova parkinsonizma je propadanje dopaminskih nevronov v kompaktnem delu črne substance, kar povzroči pomanjkanje dopamina v striatumu.To privede do nastanka klasičnih motoričnih znakov (tremor, rigidnost, akinezija, motnje ravnotežja). V zadnjih desetletjih pa patologi opisujejo tudi spremembe v limbičnem in prefrontalnem korteksu, ki povzročajo nemotorične simptome (demenca, depresija). Na področju Slovenije ni bila izvedena še nobena študija o vplivu različnih dejavnikov na kvaliteto življenja bolnikov s parkinsonizmom. 71 oseb s parkinsonizmom je kvaliteto življenja ocenilo na vidni analogni lestvici in s testom EQ 5D. Na osnovi ocene na vidni analogni lestvici sva oblikovala dve skupini. Pri preiskovancihobeh skupin sva ocenjevala motorično prizadetost, zmožnost opravljanja vsakodnevnih aktivnosti, spoznavne sposobnosti, prisotnost depresivnosti in dojemanje lastnega zdravja, pri skrbnikih pa prisotnost depresivnosti. Pokazala sva, da sta pomembna dejavnika, ki vplivata na kvaliteto življenja, depresivnost bolnika in zmožnost opravljanja vsakodnevnihaktivnosti, ne pa motorične težave ali spoznavne sposobnosti. Predlagava, da se pri kliničnem pregledu bolnika s parkinsonizmom preverjanje motorike dopolni z ocenjevanjem depresivnosti. Opravljanje vsakodnevnih aktivnosti lahko izboljšamo z multidisciplinarnim timskim pristopomTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi