54 KB127 KB50 KB192920262003Pavlin, Rudolfletnik:72številka:9str. 507-513ISSN:1318-0347COBISSID:16996057URN:URN:NBN:SI:doc-TNSHMLKOslSlovensko zdravniško društvoZdravniški vestnikAdrenal Gland NeoplasmsbiokemijaBiosynthesisBloodCarcinoid TumorChromograninsDiagnostic UsediagnostikaFeokromocitomHipertenzijaHypertensionKarcinoidni tumorKidney Failurekromogranin AKromograniniLedvična odpovedNadledvična žleza, novotvorbeNeuroendocrine TumorsNevroendokrini tumorjiPheochromocytomaProstata, novotvorbeProstatic NeoplasmsStomach NeoplasmstumorjiŽelodec, novotvorbeKromogranin A in njegova klinična uporabnost| Cromogranin A and its clinical use|Background. An old widely recepted opinion was that the medullary part of the suprarenal gland was primarily responsible for a adequate response to stress. Recently a broader significance of the gland has been recognised. The chromogranin A which is produced and secreted by its enterochromaffine cells is extensively involved in several physiological and pathological processes inthe body. Determination of the serum concentration of chromogranin A is nowadays extremely usefulfor diagnosis of the neuroendocrine tumors of the gastrointestinal tract. Conclusions. In the present article its localisation in the body and its biochemistry are described, as well as normal serum concentration values and their changes in various pathological statesIzhodišča. Staro splošno mnenje je bilo, da je sredica nadobistnice predvsem pomembna za ustrezen odziv na stres. Zdaj spoznavamo njen širši pomen. S kromograninom A, izločkom svojih kromafinih celic, in njegovimi peptidi na široko posega v fiziološka in patološka dogajanja v telesu. Določanje serumskekoncentracije kromogranina A je dandanes najbolj v rabi kot pomoč pri diagnosticiranju predvsem nevroendokrinih tumorjev prebavne cevi. Zaključki. Vprispevku so opisani: njegova razširjenost v organizmu, biokemija in normalnein patološke vrednosti pri različnih patoloških procesihTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo