{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-TNSHMLKO/57e50baa-6e16-4861-822c-035465b6310c/HTML","dcterms:extent":"54 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-TNSHMLKO/9fcd5866-31a3-4da8-b114-5e448682f78c/PDF","dcterms:extent":"127 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-TNSHMLKO/a46921ec-1d4b-41dd-840c-2310c09d5644/TEXT","dcterms:extent":"50 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-TNSHMLKO","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2003","dc:creator":"Pavlin, Rudolf","dc:format":[{"@xml:lang":"sl","#text":"letnik:72"},{"@xml:lang":"sl","#text":"številka:9"},{"@xml:lang":"sl","#text":"str. 507-513"}],"dc:identifier":["ISSN:1318-0347","COBISSID:16996057","URN:URN:NBN:SI:doc-TNSHMLKO"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"Adrenal Gland Neoplasms"},{"@xml:lang":"sl","#text":"biokemija"},{"@xml:lang":"en","#text":"Biosynthesis"},{"@xml:lang":"en","#text":"Blood"},{"@xml:lang":"en","#text":"Carcinoid Tumor"},{"@xml:lang":"en","#text":"Chromogranins"},{"@xml:lang":"en","#text":"Diagnostic Use"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"sl","#text":"Feokromocitom"},{"@xml:lang":"sl","#text":"Hipertenzija"},{"@xml:lang":"en","#text":"Hypertension"},{"@xml:lang":"sl","#text":"Karcinoidni tumor"},{"@xml:lang":"en","#text":"Kidney Failure"},{"@xml:lang":"sl","#text":"kromogranin A"},{"@xml:lang":"sl","#text":"Kromogranini"},{"@xml:lang":"sl","#text":"Ledvična odpoved"},{"@xml:lang":"sl","#text":"Nadledvična žleza, novotvorbe"},{"@xml:lang":"en","#text":"Neuroendocrine Tumors"},{"@xml:lang":"sl","#text":"Nevroendokrini tumorji"},{"@xml:lang":"en","#text":"Pheochromocytoma"},{"@xml:lang":"sl","#text":"Prostata, novotvorbe"},{"@xml:lang":"en","#text":"Prostatic Neoplasms"},{"@xml:lang":"en","#text":"Stomach Neoplasms"},{"@xml:lang":"sl","#text":"tumorji"},{"@xml:lang":"sl","#text":"Želodec, novotvorbe"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Kromogranin A in njegova klinična uporabnost| Cromogranin A and its clinical use|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. An old widely recepted opinion was that the medullary part of the suprarenal gland was primarily responsible for a adequate response to stress. Recently a broader significance of the gland has been recognised. The chromogranin A which is produced and secreted by its enterochromaffine cells is extensively involved in several physiological and pathological processes inthe body. Determination of the serum concentration of chromogranin A is nowadays extremely usefulfor diagnosis of the neuroendocrine tumors of the gastrointestinal tract. Conclusions. In the present article its localisation in the body and its biochemistry are described, as well as normal serum concentration values and their changes in various pathological states"},{"@xml:lang":"sl","#text":"Izhodišča. Staro splošno mnenje je bilo, da je sredica nadobistnice predvsem pomembna za ustrezen odziv na stres. Zdaj spoznavamo njen širši pomen. S kromograninom A, izločkom svojih kromafinih celic, in njegovimi peptidi na široko posega v fiziološka in patološka dogajanja v telesu. Določanje serumskekoncentracije kromogranina A je dandanes najbolj v rabi kot pomoč pri diagnosticiranju predvsem nevroendokrinih tumorjev prebavne cevi. Zaključki. Vprispevku so opisani: njegova razširjenost v organizmu, biokemija in normalnein patološke vrednosti pri različnih patoloških procesih"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-TNSHMLKO","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-TNSHMLKO"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-TNSHMLKO/9fcd5866-31a3-4da8-b114-5e448682f78c/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-TNSHMLKO/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-TNSHMLKO"}}}}