{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-0U23JF5P/0f63d07a-d4b2-4bc3-90d2-805d3c8856b3/HTML","dcterms:extent":"28 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-0U23JF5P/6c1f21b6-6263-4762-8260-89956ea7ede9/PDF","dcterms:extent":"245 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-0U23JF5P/20a8a5b1-2dc2-4c0d-823d-106356d9e590/TEXT","dcterms:extent":"23 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-0U23JF5P","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"2003","dc:creator":["Markovič Božič, Jasmina","Štabuc, Borut"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:37"},{"@xml:lang":"sl","#text":"7 strani"},{"@xml:lang":"sl","#text":"str. 29-35"}],"dc:identifier":["ISSN:1318-2099","COBISSID:16232665","URN:URN:NBN:SI:doc-0U23JF5P"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Association of Radiology and Oncology"},"dc:subject":[{"@xml:lang":"en","#text":"Diagnosis"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"sl","#text":"koža"},{"@xml:lang":"sl","#text":"Kožne novotvorbe"},{"@xml:lang":"sl","#text":"kožne spremembe"},{"@xml:lang":"en","#text":"Melanom"},{"@xml:lang":"en","#text":"Melanoma"},{"@xml:lang":"en","#text":"Pathology"},{"@xml:lang":"en","#text":"Plasminogen Activator Inhibitor 1"},{"@xml:lang":"en","#text":"Plasminogen Activator Inhibitor 2"},{"@xml:lang":"sl","#text":"Plazminogen aktivator, inhibitor 1"},{"@xml:lang":"sl","#text":"Plazminogenski aktivator, inhibitor 2"},{"@xml:lang":"en","#text":"Prognosis"},{"@xml:lang":"sl","#text":"Prognoza"},{"@xml:lang":"en","#text":"Skin Neoplasms"},{"@xml:lang":"en","#text":"Urokinase"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"The urokinase plasminogen activator and its inhibitors PAI-1 nad PAI-2 in primary cutaneous melanoma|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. We investigated the differences in urokinase plasminogen activator(uPA) and its inhibitors type-1 and 2 (PAI-1/2) concentrations in clinically suspected nevi, primary cutaneous melanoma and normal skin and correlations with histopathological prognostic factors of primary melanoma. Patients and methods. Fifty-one patients were enrolled. The tissue concentrations of uPA, PAI 1 and PAI2 were quantified by enzyme-linked immunosorbent assay (ELISA). Results. Mean uPA and PAI-1 concentrations in melanomas were higher than in normal surrounding skin (uPA: 1.08; vs. 0.48 ng/mgp; PAI-1: 14.07 vs. 2.07 ng/mgp; p < 0.001), uPA and PAI-1 concentrationswere higher in melanomas than in nevi, and higher in nevi than in normal surrounding skin (uPA: p > 0.05; PAI-1: p = 0.02). PAI-2 concentration was higher in normal surrounding skin than in nevi and melanomas(p > 0.05). Melanoma uPA, PAI-1 and PAI-2 concentrations correlated significantly with normal skin (r= 0.73, 0.54, 0.38 respectively). PAI 1 was significantly lower in melanomas of Breslow thickness < 0.75 mm, Clark invasion of O+I, without microscopic ulceration, without vascular invasion (p < 0.01) than in melanomas of Breslow thickness > 0.75 mm, Clark invasion > II,with ulceration and vascular invasion. Conclusions. Determination of uPA and PAI-1 can provide significant additional prognostic information for melanoma patients"},{"@xml:lang":"sl","#text":"Izhodišča. Ugotavljali smo razlike v koncentracijah urokinaznega plazminogenskega aktivatorja (uPA) in njegovih inhibitorjev tipa 1 in 2 (PAI-1/2) v klinično sumljivih nevusih, primarnem kožnem melanomu in zdravi koži v okolici ter korelacije s histopatološkimi napovednimi dejavniki primarnega melanoma. Bolniki in metode. Vključili smo 51 bolnikov. Tkivne koncentracije uPA, PAI-1 in PAI-2 smo merili z encimskoimunsko metodo (ELISA).Rezultati. Povprečne koncentracije uPA in PAI-1 v melanomih so bile višje kot v zdravi koži (uPA: 1,08; vs. 0,48 ng/mgp; PAI-1: 14,07 vs. 2,07 ng/mgp; p < 0,001). Koncentracije uPA in PAI1 so bile višje v melanomih kot v nevusih in višje v nevusih kot v zdravi koži (p > 0,05). Koncentracija PAI-2 je bila višja v zdravi koži kot v nevusih in melanomih (p > 0,05). Koncentracije uPA, PAI-1 in PAI-2 v melanomih so statistično značilno korelirale s koncentracijami v zdravi koži (r = 0,73; 0,54; 0,38). Koncentracije PAI-1 so bile statistično značilno nižje v melanomih debeline poBreslowu <_ 0,75 mm, invazije po Clarku O+I, z odsotno mikroskopsko ulceracijo, z odsotno vaskularno invazijo (p < 0,01) kot v melanomih debeline po Breslowu > 0,75 mm, invazije po Clarku > II, s prisotno mikroskopsko ulceracijo, s prisotno vaskularno invazijo. Zaključki. Z določitvijo uPA in PAI-1 lahko dobimo pomemben dodaten podatek o prognozi bolnikov z melanomom"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-0U23JF5P","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-0U23JF5P"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-0U23JF5P/6c1f21b6-6263-4762-8260-89956ea7ede9/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo radiologije in onkologije"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-0U23JF5P/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-0U23JF5P"}}}}