94 KB30 KB192920262014Cokan, AndrejaJenko Pražnikar, ZalaMakuc, JanaNikolajević, JovanaPetrovič, DanijelPopovič, DraženStare, JanezŠantl-Letonja, MarijaŠeruga, Majaletnik:83str. I-5-I-12številka:supl.ISSN:1318-0347COBISSID:24736056URN:URN:NBN:SI:doc-388LQY6SenSlovensko zdravniško društvoZdravniški vestnikaterosklerozaatherosclerosiscarotid intima-media thicknessdebelina intima medijediabetes mellitus type 2farmakogenetikaLDL receptorLDL receptor polymorphismpharmacogeneticpolimorfizemsladkorna bolezen tip 2Polymorphism Avall of the LDL receptor (rs5925) is associated with carotid-intima media thickness in patients with diabetes mellitus type 2| Polimorfizem Avall receptorja za holesterol LDL (rs5925) je povezan z debelino intime medije pri bolnikih s sladkorno boleznijo tipa 2|Increased serum level of lowdensity lipoprotein (LDL) cholesterol is a well established risk factor for atherosclerosis development and progression. Genetic variation in the LDL, receptor gene could modulate serum LDL, level and response to statin treatment thus affecting atherosclerosis development and progression. The present study was designed to investigate the association between polymorphism Avall (rs5952) of the LDL receptor gene with serum lipid levels and carotid intima-media thickness (CIMT) in patients with diabetes mellitus tyoe 2 (DM2)Povečana serumska koncentracija lipoproteinov nizke gostote (LDL) je pomemben dejavnik tveganja za pojav in napredovanje aterosleroze. Genetska variabilnost v genu za receptor LDL lahko vpliva na serumsko koncentracija LDL in odgovor na zdravljenje s statini ter tako na pojav in napredovanje ateroskleroze. V raziskavi smo želeli ugotoviti, ali obstaja povezanost med polimorfizmom Avall gena za receptor LDL (rs5925) s serumskimi ravnmi lipidov in debelino intime medije pri bolnikih s sladkorno boleznijo tipa 2(SB2),TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo