28 KB459 KB27 KB192920262012Hudler, Petraštevilka:1letnik:81str. 54-60ISSN:1318-0347COBISSID:29488089URN:URN:NBN:SI:doc-3D57MLBJslSlovensko zdravniško društvoZdravniški vestnikAdenocarcinomaAdenokarcinomAneuploidyAnevploidijaDna MethylationDNA, metilacijaGenes, Suppressor, TumorGeneticsGeni supresorski, tumorskiMicrosatellite RepeatsMikrosatelitne ponovitveMutacijaMutationOncogenesOnkogeniStomach NeoplasmsŽelodec, novotvorbeMolekularni mehanizmi, vpleteni v razvoj raka želodca| Molecular mechanisms of gastric cancer development|Background: Owing to uncharacteristic symptoms, glandular stomach cancer (adenocarcinoma) is usually diagnosed at an advanced stage, when the prognosisis poor. Research showed that these tumours are very heterogeneous interms of their molecular structure. Gastric cancer is believed to result from a multistep process encompassing different genomic, genetic and epigenetic changes. It is widely acknowledged that its development is the result of an interplay between genetic background of patients, accumulation ofalterations in genes, and environmental risk factors. Studies, conducted over the last few decades, revealed numerous mutated genes, which could be associated with the risk of gastric cancer development. Unfortunately, the pathways and molecular sequences underlying the initiation and progression of normal cells into malignant ones have not been clearly explained yet. The purpose of this review is to present molecular mechanisms most likely implicated in gastric cancer developmentTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo