34 KB111 KB30 KB192920262009Janša, Karmenletnik:78številka:8str. 387-392ISSN:1318-0347COBISSID:25922265URN:URN:NBN:SI:doc-4MWC5WY6slSlovensko zdravniško društvoZdravniški vestnikaterosklerozaAtherosclerosisBlood GlucoseBlood PressureBody Mass Indexcardiovascular diseaseCarotid ArteriesCholesteroldejavniki tveganjaDiabetes gestacijskiDiabetes, GestationalHemoglobin A glikoziliraniHemoglobin A, GlycosylatedHolesterolhuman pregnancykardiovaskularne bolezniKarotidne arterijeKrvni pritiskKrvni sladkormetabolični sindromnosečnostsladkorna bolezenTelesna masa, indeksTrigliceridiTriglyceridesTunica IntimaTunica MediaTunika intimaTunika medijaUltrasonographyPovečana debelina intime-medije karotidnih arterij in dejavniki srčno-žilne ogroženosti žensk, ki so imele nosečnostno sladkorno bolezen| Increased intima-media thickness of carotid arteries and cardiovascular risk factors in women with previous gestational diabetes mellitus|Background Women with gestational diabetes mellitus (GDM) are at an increased risk of the development of type 2 diabetes. Cardiovascular disease is the mainreason for the death of individuals with type 2 diabetes. The aim of the study was to find out if women with previous GDM already have the early signs of atherosclerosis and the components of cardiovascular disease. patients and We have compared the intima-media thickness (IMT) and metabolic and cardiovascular risk methods factors of 15 women being from three months to twoyears after delivery, with previous GDM to 9 post-gestational women with normal glucose tolerance. High-resolution ultrasonography for the noninvasive measurement of the intima-media thickness has been used. The IMT has been expressed as the mean of the three measurements of the far wall at three different sites of the carotid arteries (the common carotid artery, carotid bifurcation and internal carotid artery). The fasting blood glucose, HbA1c, lipid profile, resting blood pressure, waist circumference, body mass index and the smoking status have also been evaluated. Results Women with GDM (age 30.8 6.0 years) compared to women with normal glucose tolerance (age 29.7 2.9 years) have significantly increased IMT of all measured part of the carotid tree (mean left and right sites of the common carotid artery: 0.61 0.08 mm in GDM vs. 0.53 0.03 mm in control, p = < 0.05; carotid bifurcation:0.85 0.24 mm in GDM vs. 0.62 0.1 mm in control, p = < 0.05; internal carotid artery: 0.66 0.1 mm in GDM vs. 0.53 0.1 mm in control, p = < 0.01). The two groups significantly differ from the body mass index, body waist circumference, in the level of fasting blood glucose and triglyceride, but there are no differences between the groups in the level of whole cholesterol, HDL in LDL cholesterol, systolic and diastolic blood pressure, HbA1c and smoking status. (Abstract truncated at 2000 characters)TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo