68 KB20 KB192920262015Iglič, ČrtomirKariž, StojanKošnik, MitjaRupnik, ErikZidarn, Mihaelaštevilka:12letnik:84str. 866-870ISSN:1318-0347COBISSID:32458969URN:URN:NBN:SI:doc-565FYG33slSlovensko zdravniško društvoZdravniški vestnikangiotensin converting enzyme inhibitorsbradikininbradykininisolated angioedemaizoliran angioedemzaviralci angiotenzinove konvertazeŽivljenje ogrožajoči angioedem po zaviralcu angiotenzinove konvertaze - prikaz dveh primerov| Life-threatening angioedema induced by angiotensin-converting enzyme inhibitor - two case reports|Background. Angioedema is a rare but potentially very serious complication of treatment with angiotensin converting enzyme inhibitors (ACEI). Angioedema is due to the accumulation of bradykinin, because angiotensin converting enzyme is the key enzyme for its degradation. Case reports. We present two patients with life-threatening angioedema while taking ACEI. Both patients had already had episodes of angioedema. Angioedema didn't respond to adrenaline. In both patients intubation was difficult. Conclusion. In the acute phase of angioedema due to ACEI it is necessary to protect the airways. Bradykinin receptor inhibitors shorten the duration of episodes of angioedema. In the long term it is essential to permanently avoid ACEITEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo