{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-5LXP32CZ/154d9942-76e7-4c29-86b1-750cb4a35bf2/HTML","dcterms:extent":"34 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-5LXP32CZ/5f2b9426-6edf-42bb-94ad-b5cf509a743c/PDF","dcterms:extent":"82 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-5LXP32CZ/44603e84-be77-4c56-8e86-e3b1a775e9f4/TEXT","dcterms:extent":"31 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-5LXP32CZ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2005","dc:creator":["Brvar, Miran","Bunc, Matjaž","Možina, Hugon","Možina, Martin"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:74"},{"@xml:lang":"sl","#text":"str. 239-243"}],"dc:identifier":["ISSN:1318-0347","COBISSID:19202009","URN:URN:NBN:SI:doc-5LXP32CZ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"Antidotes"},{"@xml:lang":"sl","#text":"Antidoti"},{"@xml:lang":"en","#text":"Calcium Channel Blockers"},{"@xml:lang":"en","#text":"drug"},{"@xml:lang":"en","#text":"Glucagon"},{"@xml:lang":"sl","#text":"Glukagon"},{"@xml:lang":"en","#text":"Insulin"},{"@xml:lang":"sl","#text":"Inzulin"},{"@xml:lang":"sl","#text":"Kalcijev kanalček, blokatorji"},{"@xml:lang":"sl","#text":"kalcijevi antagonisti"},{"@xml:lang":"sl","#text":"Kalij"},{"@xml:lang":"en","#text":"Kalij Pheasant"},{"@xml:lang":"en","#text":"Overdose"},{"@xml:lang":"en","#text":"Poisoning"},{"@xml:lang":"en","#text":"Potassium"},{"@xml:lang":"sl","#text":"predoziranje"},{"@xml:lang":"sl","#text":"Prekomerna doza"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"zastrupitve"},{"@xml:lang":"sl","#text":"zdravila"},{"@xml:lang":"sl","#text":"zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Zastrupitve z zaviralci kalcijevih kanalčkov| Calcium channel blocker poisoning|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Calcium channel blockers act at L-type calcium channels in cardiacand vascular smooth muscles by preventing calcium influx into cells with resultant decrease in vascular tone and cardiac inotropy, chronotropy anddromotropy. Poisoning with calcium channel blockers results in reduced cardiac output, bradycardia, atrioventricular block, hypotension and shock. The findings of hypotension and bradycardia should suggest poisoning with calcium channel blockers. Conclusions. Treatment includes immediate gastric lavage and whole-bowel irrigation in case of ingestion of sustained release products. All patients should receive an activated charcoal orally. Specific treatment includes calcium, glucagone and insulin, which proved especially useful in shocked patients. Supportive care including the use of catecholamines is not always effective. In the setting of failure of pharmacological therapy transvenous pacing, balloon pump and cardiopulmonary by pass may be necessary"},{"@xml:lang":"sl","#text":"Izhodišča. Zaviralci kalcijevih kanalčkov zavirajo kalcijeve kanalčke tipa L vsrčnomišičnih in žilnih gladkomišičnih celicah in preprečujejo vstop kalcija v celice. S tem znižujejo žilni tonus ter delujejo negativno inotropno, kronotropno in dromotropno. Zastrupljenci z zaviralci kalcijevih kanalčkov imajo zmanjšan minutni volumen srca, bradikardijo, preddvorno prekatni blok, hipotenzijo in šok. Na zastrupitev s kalcijevimi kanalčki moramo pomisliti privseh bolnikih, ki so hipotenzivni in hkrati bradikardni. Zaključki. Zdravljenje vključuje takojšnjo dekontaminacijo prebavil z izpiranjem želodca.Če pa so zaužili pripravke s počasnim sproščanjem, tudi izpiranje črevesja. Vsi bolniki morajo prejeti aktivno oglje. Specifično zdravljenje vključuje kalcij, glukagon in insulin, ki se je pokazal za posebno učinkovit antidot pri šokiranih bolnikih. Običajno je potrebno tudi podporno zdravljenjes simpatikomimetiki, ki pa ni vedno učinkovito. V primeru, da se bolnikovo stanje ne izboljša ob zdravjenju z zdravili, lahko uporabimo srčni spodbujevalnik, balonsko aortno črpalko in srčnožilni obvod"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-5LXP32CZ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-5LXP32CZ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-5LXP32CZ/5f2b9426-6edf-42bb-94ad-b5cf509a743c/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-5LXP32CZ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-5LXP32CZ"}}}}