{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-5QAG32VI/93928129-4a5c-4593-b256-10a4794f7ed9/PDF","dcterms:extent":"527 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-5QAG32VI/ca039fa8-ef1c-49e7-bc60-c88696fc6e74/TEXT","dcterms:extent":"25 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-5QAG32VI","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"1997","dc:creator":["Bohuslavizki, Karl H...","Brenner, Winfried","Clausen, Malte","Feyerabend, Bernd","Henze, Eberhard","Hübner, Ralf-Harto","Klutmann, Susanne","Lüttges, Jutta","Mester, Janos","Tinnemeyer, Stephan"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:31"},{"@xml:lang":"sl","#text":"str. 279-285"}],"dc:identifier":["ISSN:1318-2099","COBISSID_HOST:7387097","URN:URN:NBN:SI:doc-5QAG32VI"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Croatian Medical Association - Croatian Society of Radiology"},{"@xml:lang":"sl","#text":"Slovenian Medical Society - Section of Radiology"}],"dc:subject":[{"@xml:lang":"sl","#text":"Adverse effects"},{"@xml:lang":"sl","#text":"Amifostine"},{"@xml:lang":"sl","#text":"Iodine radioisotopes"},{"@xml:lang":"sl","#text":"Rabbits"},{"@xml:lang":"sl","#text":"Radiation effects"},{"@xml:lang":"sl","#text":"Radiation-protective agents"},{"@xml:lang":"sl","#text":"Radionuclide imaging"},{"@xml:lang":"sl","#text":"Radiotherapy"},{"@xml:lang":"sl","#text":"Salivary glands"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Radioprotection of salivary glands by amifostine in high-dose radioiodine therapy investigated in a new rabbit animal model|"},"dc:description":{"@xml:lang":"sl","#text":"Salivary gland damage following high-dose radioiodine treatment (HD-RIT) is a well known side effect. Since differentiated thyroid cancer (DTC) has a very good prognosis, the reduction of long-term side effect is of major interest. Therefore, the radioprotective effect of amifostine was investigated in a rabbit animal model. Quantitative salivary gland scintigraphy was performed on5 rabbits prior to and up to 3 months after HD-RIT applying 1 GBq I-131. Theuptake of Tc-99cm-pertechnetate was calculated as a measure of parenchymal function. Three animals received 200 mg/kg amifostine prior to HD-RIT, and twoserved as controls. Salivary glands were examined histopathologically. In two control rabbits HD-RIT significantly (p<0.001) reduced pertechnetate uptake by 63% and 46% in parotid and submandibular glands, respectively, and lipomatosis was found histopathologically. In contrast, in three rabbits treated with amifostine parenchymal function was not decreased significantly (p=0.953), and lipomatosis was negligible. In conclusion, salivary gland impairment induced by HD-RIT can be evaluated quantitatively by salivary glandscintigraphy in rabbits, and amifostine significantly reduced salivary gland damage induced by HD-RIT. These encouraging results need furtner evaluation in patients since in may help to increase the quality of life of patients with diffentiated thyroid cancer"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-5QAG32VI","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-5QAG32VI"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-5QAG32VI/93928129-4a5c-4593-b256-10a4794f7ed9/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Onkološki inštitut Ljubljana"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-5QAG32VI/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-5QAG32VI"}}}}