1582 KB64 KB192920262023Gašperlin, MirjanaGosenca Matjaž, MirjamVitek, MercedesZvonar Pobirk, Alenkaštevilka:1-2letnik:92str. 79-92DOI:10.6016/ZdravVestn.3331COBISSID_HOST:128269059ISSN:1581-0224URN:URN:NBN:SI:doc-5QIFJ1PMslSlovensko zdravniško društvoZdravniški vestnikactive skin careaktivna nega kožeatopic dermatitisatopijski dermatitisbolezni kožecorticosteroidesDostavni sistemikortikosteroidilipid-based delivery systemslipidni dostavni sistemimedicinesskin diseaseszdravilaIzzivi in sodobni pristopi k zdravljenju atopijskega dermatitisa| Challenges and modern approaches to the treatment of atopic dermatitis|Atopic dermatitis is the most common chronic inflammatory skin disease, characterized by changes in skin structure manifesting through red, dry and scaly areas accompanied by itching. Due to its complexity, the disease represents a considerable therapeutic challenge. Thus, up-to-date treatment guidelines emphasise the importance of comprehensive treatment. Regular and proper skincare with cosmetic products containing active ingredients that restore impaired skin barrier function through various mechanisms is of great importance. Further, depending on the degree of inflammation and the extent of skin lesions, drugs for local or systemic treatment are required. According to the standard therapeutic modalities, drugs for local therapy are used as long as the patient responds. Typically, active ingredients for dermal administration intended for active skincare and/or therapy are incorporated into conventional dosage forms such as ointments, creams, dermal solutions, and emulsions. However, in recent years major advances have been made toward developing innovative lipid-based delivery systems, such as lyotropic liquid crystals, micro- and nano-emulsions, vesicular systems, and lipid nanoparticles. The present paper systematically reviews active ingredients for skincare of atopic skin along with drugs and dosage forms registered in Slovenia for the treatment of atopic dermatitis . Concurrently, attractive scientific researches, patent publications and new achievements in innovative lipid-based delivery systems are presented, proving their unique advantages that enable patient-friendly treatment and improved therapeutic outcomesAtopijski dermatitis je najpogostejša kronična vnetna bolezen kože, za katero so značilne spremembe v strukturi kože. Kažejo se kot pordeli, suhi in luščeči se predeli, ki jih spremlja srbenje. Ker gre za izredno kompleksno bolezen, ki predstavlja velik terapevtski izziv, sodobne terapevtske smernice poudarjajo pomen celovitega zdravljenja. Zelo pomembna je redna in pravilna nega atopijske kože z izdelki z aktivnimi sestavinami, ki po različnih mehanizmih delovanja obnavljajo njeno okrnjeno pregradno vlogo. V odvisnosti od stopnje vnetja in obsega kožnih sprememb se poslužujemo lokalne ali sistemske terapije, pri čemer velja, da prvenstveno uporabljamo zdravila za lokalno zdravljenje, dokler je to mogoče oziroma se bolnik nanje odziva. Običajno so učinkovine za nanos na kožo, ki so namenjene aktivni negi in/ali zdravljenju, vgrajene v klasične formulacije, kot so mazila, kreme, dermalne raztopine in emulzije. V zadnjih letih pa se intenzivno razvijajo predvsem inovativni lipidni dostavni sistemi, kot so liotropni tekoči kristali, mikro- in nanoemulzije, vezikularni sistemi in lipidni nanodelci. V prispevku so tako sistematično zbrane in predstavljene aktivne sestavine sodobnih kozmetičnih izdelkov za nego atopijske kože ter zdravilne učinkovine in farmacevtske oblike, registrirane v Sloveniji za zdravljenje atopijskega dermatitisa. Hkrati prikazujemo atraktivne znanstvene raziskave, patentne objave in novosti na področju inovativnih lipidnih dostavnih sistemov s temi učinkovinami, ki kažejo na edinstvene prednosti teh formulacij, ki omogočajo bolniku prijaznejše zdravljenje in s tem izboljšani terapevtski izidTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo