{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-6BO5U0KF/9f355abd-9a31-4626-9358-a2c80e670c29/HTML","dcterms:extent":"42 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-6BO5U0KF/58bb3ce7-6fed-448b-b736-eefd577575e2/PDF","dcterms:extent":"321 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-6BO5U0KF/50eb7d46-68d3-49e4-89e7-9e510442e92c/TEXT","dcterms:extent":"34 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-6BO5U0KF","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2012","dc:creator":["Černelč, Peter","Domanovič, Dragoslav","Haddad, F.","Ležaič, Luka","Poglajen, Gregor","Sever, Matjaž","Torre-Amione, Guillermo","Vrtovec, Bojan"],"dc:format":[{"@xml:lang":"sl","#text":"letnik:81"},{"@xml:lang":"sl","#text":"str. II-373-II-383"},{"@xml:lang":"sl","#text":"številka:suppl."}],"dc:identifier":["ISSN:1318-0347","COBISSID:699564","URN:URN:NBN:SI:doc-6BO5U0KF"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"dilated cardiomyopathy"},{"@xml:lang":"sl","#text":"dilativna kardiomiopatija"},{"@xml:lang":"en","#text":"heart failure"},{"@xml:lang":"sl","#text":"matične celice"},{"@xml:lang":"sl","#text":"srčno popuščanje"},{"@xml:lang":"en","#text":"stem cells"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Long-term effects of stem cell transplantation in heart failure| Dolgoročni učinki presaditve matičnih celic pri bolnikih s srčnim popuščanjem|"},"dc:description":{"@xml:lang":"sl","#text":"Background: We investigated long-term effects of intracoronary transplantationof CD34+ cells in patients with dilated cardiomyopathy (DCM). Methods: Of 110 DCM patients, 55 were randomized to CD34+ cell transplantation(SC) group, and 55 patients received no cell therapy (controls). In the SC group, peripheral CD34+cells were mobilized by G-CSF andcollected via apheresis. Patients underwent myocardial scintigraphy and CD34+ cells were injected in the artery supplying the segments with reduced viability. Patients were followed for 5 years. Results: At baseline, the 2 groups did not differ in age, gender, left ventricular ejection fraction (LVEF), or NT-proBNP levels. At 5 years, stem cell therapy was associated withan increase in LVEF (from 24.3 Ž 6.5 % to 30.0 Ž 5.1 %; P = 0.02), an increase in 6-minute walk distance (from 344 Ž 90 m to 477 Ž 130 m; P < 0.001), and a decrease in NT-proBNP (from 2322 Ž 1234 pg/mL to 1011 Ž 893 pg/mL; P < 0.01). During followup, 27 (25 %) patients died and 9 (8 %) underwent heart transplantation. Of the 27 deaths, 13 were attributed to pump failure, and 14 to sudden cardiac death. Total mortality was lower in SC group(8/55 14 %) than in controls (19/55 35 %) (P = 0.01). The same was true of pump failure (3/55 5 % vs. 10/55 18 %, P = 0.03), but not of sudden cardiac death (5/55 9 % vs. 9/55 16 %, P = 0.39). SC therapy was anindependent predictor of outcome on multivariable analysis (P = 0.04). Conclusions: Intracoronary stem cell transplantation may be associated with improved ventricular remodeling, exercise tolerance, and longterm survival in patients with DCM"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-6BO5U0KF","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-6BO5U0KF"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-6BO5U0KF/58bb3ce7-6fed-448b-b736-eefd577575e2/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-6BO5U0KF/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-6BO5U0KF"}}}}