1819 KB18 KB199220251998Poljak-Blaži, MarijaPopović-Hadžija, Marijanaštevilka:1letnik:32str. 47-52ISSN:1318-2099COBISSID_HOST:7653337URN:URN:NBN:SI:doc-77ZBW86IenCroatian Medical Association - Croatian Society of RadiologySlovenian Medical Society - Section of RadiologyRadiology and oncology (Ljubljana)Genes, bcl-2ImmunologyLeukemia, myeloidMiceProto-oncogene proteins c-bcl-2SpleenUltraviolet raysDifferential expression of Bcl-2 protein in non-irradiated or UVC-irradiated murine myleoid leukaemia (ML) cells| Razlika v ekspresiji proteina Bcl-2 v mieloidno leukemičnih celicah pri obsevanih miših z ultravijoličnimi žarki in pri neobsevanih miših|In this work, we examined the expression of Bcl-2 protein in myueloid leukaemia (ML) cells and the effect of UVC-light on the expression level. The protein of bcl-2 oncogene was detected by immunocytochemical method. In spleencells of healthy RFM donors was detected 34.3% of Bcl-2 positive cells. When leukaemia came to the non terminal phase (NTP) more than 50% of cells expressed this protein. However, in terminal phase (TP) of leukaemia growth, only 24.4% Bcl-2 positive cells was determined. After UVC irradiation, the expression of Bcl-2 protein was significantly higher in spleen cells of healthy donors. However, UVC light did not change the expression of Bcl-2 in cells of both investigated phases of ML growth. Bcl-2 protein may be involved in the resistance of ML cells to UVC lightTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaOnkološki inštitut Ljubljana