41 KB91 KB26 KB192920262008Glaser, Marjana5 straništevilka:6/7letnik:77str. 447-451ISSN:1318-0347COBISSID:3014975URN:URN:NBN:SI:doc-7WW9O3OXslSlovensko zdravniško društvoZdravniški vestnikAgamaglobulinemijaAgammaglobulinemiaImmunoglobulins, IntravenousImunoglobulini, intravenskiimunologijaintravenski imunoglobulinikrvne bolezniLimfoproliferativne motnjeLymphoproliferative DisordersMultiple MyelomaMultipli mielompripravkiPurpura, Thrombocytopenic, IdiopathicPurpura, trombocitopenična, idiopatskatherapyzdravljenjePomen intravenskih imunoglobulinov pri zdravljenju krvnih bolezni odraslih| The importance of intravenous immunoglobulins in the treatment of adult hematological diseases|Intravenous immunoglobulins (IVIG) are preparations made from human plasma and contain beside immunoglobulin G a wide spectrum of other endemic antibodies against infectious disease typical for Slovenia. The purpose of treatment with IVIG is to restore normal immunoregulatory mechanisms in human body. The use of IVIG is different: as replacement therapy in primary and secondary immunodidefficiency (lack of antibodies, impossibility of producing antibodies), as prophylactic treatment of some infections (cytomegalovirus, parvovirus B19) and for treatment of autoimmune diseases as idiopathic thrombocytopenic purpura. Conclusions. As showed with pharmacokinetics study in patients with chronic lymphocytic leukemia and multiple myeloma, IVIG has no influence on normal distribution of IgG and other antibodies. In the paper there are shown multiple possible mechanisms of IVIG action, although they haven't been understood yet. There is a big possibility that some other antibodies, which are present in the IVIG, are involved. The relative good effect of IVIG treatment in different hematological diseases became of interest for prevention and treatment of some neurologic and neuromuscular diseasesIntravenski imunoglobulini (IVIG) so pripravki, narejeni iz človeške plazme, ki vsebujejo poleg imunoglobulina G še širok spekter protiteles za Slovenijo endemičnih povzročiteljev kužnih bolezni ter druge snovi. Uporaba pripravkov IVIG omogoča vzpostavitev normalnih imunoregulacijskih mehanizmov v telesu. Je kot nadomestno zdravljenje pri primarni in sekundarni imunski pomanjkljivosti (pomanjkanje protiteles, nezmožnost tvorbe protiteles), kot profilaktično zdravljenje pri nekaterih okužbah (citomegalovirus, parvovirus B19) ter kot zdravljenje avtoimunih bolezni, kot je idiopatska trombocitopenična purpura. Zaključki. S farmakokinetsko raziskavo pri bolnikih s kronično limfocitno levkemijo in plazmocitomom so dokazali, da priprava IVIG ne vpliva na normalno naravno porazdelitev IgG in drugih protiteles v pripravku. Številni možni mehanizmi za prikaz delovanja IVIG do danes še niso povsem razumljivi. Druga protitelesa v IVIG so zelo verjetno vpletena v delovanje. Sorazmerno dober učinek IVIG pri krvnih boleznih je postal zanimiv tudi za preprečevanje in zdravljenje nevroloških ter mišično-živčnih bolezniTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo