{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-9CQ18LUF/f3c3e43c-a846-41c8-ad1b-949dbfa7d125/PDF","dcterms:extent":"245 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-9CQ18LUF/e42aa68a-f2a1-4eab-9e52-0eb75f3a3480/TEXT","dcterms:extent":"46 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-9CQ18LUF/d6430e30-558f-4158-82ee-8e54b286d9e0/PDF","dcterms:extent":"246 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-9CQ18LUF/96891a15-3550-45ba-b83c-34056c56b6bd/TEXT","dcterms:extent":"45 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-9CQ18LUF","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2024","dc:creator":["Berce, Ingrid","Dermota, Urška","Harlander, Tatjana","Lugovski, Marica","Ribič, Helena","Žohar Čretnik, Tjaša"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1/2"},{"@xml:lang":"sl","#text":"letnik:93"},{"@xml:lang":"sl","#text":"str. 72-80"}],"dc:identifier":["DOI:10.6016/ZdravVestn.3448","ISSN:1318-0347","COBISSID:180864003","URN:URN:NBN:SI:doc-9CQ18LUF"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"Escherichia coli"},{"@xml:lang":"sl","#text":"fosfomicin"},{"@xml:lang":"sl","#text":"nitrofurantoin"},{"@xml:lang":"sl","#text":"Staphylococcus saprophyticus"},{"@xml:lang":"sl","#text":"trimetoprim sulfametoksazol"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Občutljivost za antibiotike pri povzročiteljih nezapletenega cistitisa v Sloveniji| Antimicrobial susceptibility of bacteria causing uncomplicated cystitis in Slovenia|"},"dc:description":[{"@xml:lang":"sl","#text":"Background: Acute uncomplicated cystitis in women is a common reason for antibiotic treatment in the outpatient clinic of family doctors. Microbiological diagnostics is not indicated; treatment is generally empirical and based on guidelines and recommendations. Therefore, we do not have representative data on the incidence and sensitivity of pathogens from regular laboratory work. Special targeted research is needed. Methods: We present the results of the prospective research conducted in four regional laboratories of the Centre for Medical Microbiology NLZOH between 15 September 2017 and 31 December 2019. We included 110 female patients with suspected acute uncomplicated cystitis who completed a questionnaire and submitted urine samples for microbiological examination. Results: The result of urine examination was positive in 79 patients (71.8%). Among all isolates, the most common bacterium was Escherichia coli (74%), followed by Staphylococcus saprophyticus (10%), and others. The susceptibility of E. coli to trimethoprim with sulfamethoxazole was 85.5%, to nitrofurantoin 98.4%, and to fosfomycin 100%. S. saprophyticus isolates were susceptible to the tested antibiotics except for fosfomycin, against which the bacterium is intrinsically resistant. The total susceptibility of all isolates was 85.8% - 88.2% for trimethoprim with sulfamethoxazole, 88.1% - 95.2% for nitrofurantoin, 73.8% - 80.8% for fosfomycin, 72.6% for ampicillin and amoxicillin, 97.7% for cefadroxil, and 98.9% for amoxicillin with clavulanate acid. A comparison with the results of monitoring bacterial resistance as part of the regular work of microbiological laboratories shows significant differences for most of the tested antibiotics. Conclusion: The research results show a relatively good susceptibility of the causative agents of acute uncomplicated cystitis to oral antibiotics, the only exception being amoxicillin"},{"@xml:lang":"sl","#text":"Izhodišče: Akutni nezapleteni cistitis pri ženskah je pogost razlog za zdravljenje z antibiotiki v ambulanti družinskih zdravnikov. Mikrobiološke preiskave niso indicirane, zdravljenje je praviloma izkustveno in temelji na smernicah in priporočilih. Zato reprezentativnih podatkov o pojavnosti in občutljivosti povzročiteljev iz rednega dela laboratorijev nimamo. Potrebne so posebne usmerjene raziskave. Metode: V prispevku obravnavamo rezultate prospektivne raziskave, ki smo jo v štirih regionalnih laboratorijih Centra za medicinsko mikrobiologijo NLZOH izvedli v času od 15. 9. 2017 do 31. 12. 2019. V raziskavo smo vključili 110 bolnic s sumom na akutni nezapleteni cistitis, ki so izpolnile vprašalnik in oddale vzorec seča za urinokulturo. Rezultati: Rezultat preiskave seča je bil pozitiven pri 79 bolnicah (71,8 %). Med vsemi izolati je bila najpogostejša bakterija Escherichia coli (74 %), sledila je bakterija Staphylococcus saprophyticus (10 %) in druge. Občutljivost E. coli za trimetoprim s sulfometoksazolom je bila 85,5 %, za nitrofurantoin 98,4 % in za fosfomicin 100 %. Izolati S. saprophyticus so bili dobro občutljivi za vse testirane antibiotike razen za fosfomicin, proti kateremu je bakterija naravno odporna. Skupna občutljivost vseh izolatov je bila za trimetoprim s sulfometoksazolom 85,8– 88,2 %, za nitrofurantoin 88,1–95,2 %, za fosfomicin 73,8–80,8 %, za ampicilin in amoksicilin 72,6 %, za cefadroksil 97,7 % in za amoksicilin s klavulansko kislino 98,9 %. Primerjava z rezultati spremljanja odpornosti bakterij v okviru rednega dela mikrobioloških laboratorijev kaže velike razlike pri večini testiranih antibiotikov. Zaključek: Rezultati raziskave kažejo razmeroma dobro občutljivost povzročiteljev akutnega nezapletenega cistitisa za peroralne antibiotike, izjema je le amoksicilin"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-9CQ18LUF","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-9CQ18LUF"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-9CQ18LUF/f3c3e43c-a846-41c8-ad1b-949dbfa7d125/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-9CQ18LUF/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-9CQ18LUF"}}}}