{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-A6YXCY1M/972a9f14-fae7-4808-bfbd-59a1a87251f8/PDF","dcterms:extent":"452 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-A6YXCY1M/ef0f9b62-65e1-4632-81cf-d21ded125936/TEXT","dcterms:extent":"27 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-A6YXCY1M","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"1997","dc:creator":["Budach, V...","Döker, R...","Grabenbauer, Gerhard G.","Huber, K...","Hültenschmidt, B...","Hutter, M...","Kuhne-Velte, H... J.","Panzer, M...","Rühl, U...","Wendt, T... G."],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:31"},{"@xml:lang":"sl","#text":"str. 219-226"}],"dc:identifier":["ISSN:1318-2099","COBISSID_HOST:7173593","URN:URN:NBN:SI:doc-A6YXCY1M"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Croatian Medical Association - Croatian Society of Radiology"},{"@xml:lang":"sl","#text":"Slovenian Medical Society - Section of Radiology"}],"dc:subject":[{"@xml:lang":"sl","#text":"Carcinoma, squamous cell"},{"@xml:lang":"sl","#text":"Drug therapy"},{"@xml:lang":"sl","#text":"Fluorouracil"},{"@xml:lang":"sl","#text":"Mitomycin c"},{"@xml:lang":"sl","#text":"Multicenter studies"},{"@xml:lang":"sl","#text":"Neoplasm staging"},{"@xml:lang":"sl","#text":"Radiotherapy"},{"@xml:lang":"sl","#text":"Rectal neoplasms"},{"@xml:lang":"sl","#text":"Survival analysis"},{"@xml:lang":"sl","#text":"Treatment outcome"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Combined radiation and chemotherapy for squamous cell carcinoma of the anal canal: results and prognostic variables in a multiinstitutional series of 173 patients|"},"dc:description":{"@xml:lang":"sl","#text":"Purpose: This retrospective multicenter study was aimed to asses the effect ofcombined modality therapy in patients with squamous cell carcinoma of the anal canal, stage T1-4 NO-3 MO. Patients and methods: Between 1985 and 1994, 173 patients underwent treatment by combined radiation and chemotherapy. A median total dose of 50 Gy was delivered to the primary, perirectal, presacraland inguinal nodes, followed by a local boost in selected cases. 5-Fluorouracil was scheduled as a continuous infusion of 1000 mg/m2/24 h on days 1-5 and 29-33, and mitomycin C as bolus of 10 mg/m2 on days 1 and 29. Results: Cancer related survival (OS), NED-survival and local control rates at5 years were 71+-5%, 59+-4% and 67+-4%, respictively. Anorectal function waspreserved in 91% of the patients in whom the primary was controlled. Only 9.6% experienced severe late toxicity requiring surgery. In univariate analysis, T category (T1/2 vs. T3/4) was predictive for OS (83+-4% vs. 53+-9%,p=0.01), NED-surival (75+-4% vs. 36+-7%, p<0.0001) and local control (81+-4% vs. 46+-7%, p<0.0001). N category (NO vs. N1-3) influenced NED-servival (66+-5% vs. 33+-12%, p=0.004) and local control (76+-4% vs. 37+-13%, p=0.003). Treatment technique (<2 fields vs. 2 fields) was found to be of prognostic value for NED-surival (70+-6%, sv. 50+-6%, p=0.016) and localcontrol (77+-6% vs.58+-6%, p=0.018). Only in T3/4 cases the total RT-dose(<45 Gy vs. 45 Gy) had an impact on NED-survival (42+-7% vs. 23+-13%, p=0.01) and local control (52+-8% vs. 45+-15%, p=0.03). In multivariate analysis, the T category (UICC 1922) remained the only significant variable with impact on survival (p=0.04), NED-survival (p<0.001) and local control (p=0.003). Conclusion: Treatment with a combination of radiotherapy and chemotherapy is safe and effective for patients with anal canal carcinoma. Theimprovement of results in advanced stages is warranted"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-A6YXCY1M","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-A6YXCY1M"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-A6YXCY1M/972a9f14-fae7-4808-bfbd-59a1a87251f8/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Onkološki inštitut Ljubljana"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-A6YXCY1M/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-A6YXCY1M"}}}}