{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AMZIAK4F/ab15dc7e-0a07-4e41-b04d-da986f394629/HTML","dcterms:extent":"35 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AMZIAK4F/d2cc7ffe-60bc-4535-a272-deca80e5b32f/PDF","dcterms:extent":"425 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AMZIAK4F/d1ead77e-5927-4e82-9aff-8be6db465896/TEXT","dcterms:extent":"29 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-AMZIAK4F","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2011","dc:creator":["Gavrić-Lovrec, Vida","Hojnik, Nina","Kovač, Vilma","Kovačič, Borut","Mlakar, Lea","Reljič, Milan","Vlaisavljević, Veljko"],"dc:format":[{"@xml:lang":"sl","#text":"letnik:80"},{"@xml:lang":"sl","#text":"str. I-20-I-27"},{"@xml:lang":"sl","#text":"številka:supl."}],"dc:identifier":["ISSN:1318-0347","COBISSID:3926335","URN:URN:NBN:SI:doc-AMZIAK4F"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"fertilization"},{"@xml:lang":"sl","#text":"oploditev"},{"@xml:lang":"sl","#text":"oploditev z biomedicinsko pomočjo"},{"@xml:lang":"sl","#text":"reprodukcija"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Implementation of blastocyst transfer in the routine clinical practice of assisted reproductive techniques| analiza 6000 zaporednih ciklov| analysis of 6000 consecutive cycles| Vključitev prenosa blastociste v rutinsko klinično delo pri oploditvah z biomedicinsko pomočjo|"},"dc:description":[{"@xml:lang":"sl","#text":"Background: All patients who entered our assisted reproductive technology (ART) program during last 7 years were analyzed in order to compare the outcome of in vitro fertilization (IVF) cycles after early cleavage stage embryo transfers and blastocyst transfers. Methods: All patients with successful oocyte pick up (OPU) after controlled ovarian hiperstimulation in the period from 2002 to 2008 were included in this retrospective analysis. The cycles were stratified with respect to the number of aspirated oocytes as follows: poor responders in whom only a single oocyte was aspirated, low responders with 2 to 4 oocytes, and good responders with more than 4 oocytes retrieved. Pregnancy, delivery and multiple delivery rates were calculated and compared between the cycles with day 3 and cycles with day 5 embryo transfers. Results: Among 6098 included patients, 292 (4.8 %) were poor, 1450 (23.8 %) low and 4356 (71.4 %) good responders. Total fertilization failure was observed in 5.7 % (350/6098) of all cycles. Among the cycles with fertilization, embryo transfer on day 3 was planned in 1940 (33.9 %) cycles and blastocyst transfer on day 5 in 3788 (66.1 %) cycles. Transfer was cancelled in 6.8 % (394/5748) of cycles, more frequently after embryo culturing in vitro for 5 than for 3 days (7.8 % vs. 6.1 %). However, more women delivered after blastocyst transfer compared to early stage embryo transfers in low (9.5 % vs. 6.1 %), poor (23.7 % vs. 15.2 %) and normal (39.9% vs. 17.3 %) responders. Multiple delivery rate was also higher after blastocyst rather then after early embryo transfers in low (24.3 % vs. 13.3 %) and normal (29.4 % vs. 24.6 %) responders. Conclusions: The transfer of blastocyst stage embryos increases the success rate of ART procedures in all patients. To avoid multiple pregnancies, single blastocyst transfer is recommended"},{"@xml:lang":"sl","#text":"Izhodišče: S študijo smo želeli primerjati uspešnost postopkov oploditve z biomedicinsko pomočjo (OBMP) po prenosu zgodnjih zarodkov in po prenosu blastocist pri vseh bolnikih, ki so bili v zadnjih 7 letih vključeni v program zdravljenja s tehnikami asistirane reprodukcije (ART). Metode: V nerandomizirano retrospektivno študijo smo vključili vse ženske z uspešno aspiracijo jajčnih celic po kontrolirani ovarijski hiperstimulaciji (KOH) med letoma 2002 in 2008. Cikle smo razdelili glede na število osamljenih jajčnih celic na slabo odzivne, pri katerih smo dobili le eno jajčno celico; nizko odzivne, kjer smo aspirirali 2-4 jajčne celice, in dobro odzivne, kjer smo v aspiratu našli več kot 5 jajčnih celic. Izračunali in primerjali smo deleže nosečnosti, porodov in mnogoplodnih porodov pri ciklih, pri katerih smo opravili prenos zarodkov na tretji oziroma peti dan po aspiraciji foliklov. Rezultati: Med 6098 vključenimi bolniki je bilo 292 (4,8 %) slabo odzivnih, 1450 (23,8 %) nizko odzivnih in 4356 (71,4 %) dobro (normalno) odzivnih. V 5,7 % (350/6098) vseh ciklov smo zabeležili popolno odsotnost oploditve jajčnih celic. V ciklih, v katerih so se jajčne celice oplodile, smo prenos zarodkov na tretji dan razvoja načrtovali pri 1940 (33,9 %) parih, prenos blastocist na peti dan razvoja pa pri 3788 (66,1 %) parih. V 6,8 % (394/6098) ciklov prenosa zarodkov nismo naredili, in sicer pogosteje po petdnevnem kot po tridnevnem gojenju zarodkov (7,8 % oz. 6,1 %). Kljub temu je več žensk zanosilo po prenosu blastocist kot po prenosu zgodnjih zarodkov v skupini z nizko odzivnostjo (9,5 % oz. 6,1 %), slabo odzivnostjo (23,7 % oz. 15,2 %) in dobro odzivnostjo (39,9 % oz. 17,3 %). Tudi delež večplodnih porodov je bil višji po prenosu blastocist kot po prenosu zgodnjih zarodkov, in sicer tako pri nizko odzivnih (24,3 % oz. 13,3 %) kot tudi pri dobro odzivnih ciklih (29,4 % oz. 24,6 %). Zaključek: Prenos zarodkov, razvitih do stopnje blastociste, poviša delež uspešnosti v postopkih zunajtelesne oploditve pri vseh bolnikih. Za preprečitev večplodnih nosečnosti priporočamo prenos le ene blastociste"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-AMZIAK4F","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-AMZIAK4F"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-AMZIAK4F/d2cc7ffe-60bc-4535-a272-deca80e5b32f/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-AMZIAK4F/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-AMZIAK4F"}}}}