287 KB18 KB199220251997Došen, DanijelJanušić, RenatoKrajina, ZdenkoMršić-Krmpotić, ZrinkaŠmalcelj, JosipTurić, Markoštevilka:2letnik:31str. 181-185ISSN:1318-2099COBISSID_HOST:7176921URN:URN:NBN:SI:doc-AYQNP0JOenCroatian Medical Association - Croatian Society of RadiologySlovenian Medical Society - Section of RadiologyRadiology and oncology (Ljubljana)Drug therapyNasopharyngeal neoplasmsRadiotherapySurvival analysisCombined therapy of undifferentiated carcinoma of nasopharyngeal type|From November 1989 to October 1993, 339 patients with stage IV undifferentiated carcinoma of nasopharyngeal type (UCNT) were enrolled in a randomized trial comparing neoadjuvant chemotherapy (cisplation, epirubicin, bleomycin - BEC) plus radiotherapy (171 patients) vs. radiotherapy alone (168 patients). All patient characteristics were well-balanced in both arms. The overall response rate assessed clinically by the investigator at the end of chemotherapy was 91% (WHO) with 47% CR and 4% PR. Three months after the completion of radiotherapy, a CR (clinical + CT scan) was observed in 55% of the combined treatment group compared to 34% in the radiotherapy-alone group (p<0.01). Tumor recurrence or progression was observed in 55/171 patients in the chemotherapy arm (32.7%), compared to 92/168 patients in the radiotherapy-alone arm (54.7%) (p<0.01). In conclusion, the addition of BEC type chemotherapy, has changed the proportion of UCNT patients continously disease free but the overall survival data are not yet matureTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaOnkološki inštitut Ljubljana