{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AYQNP0JO/8959bac6-cf27-449a-bccf-510e1562ebd3/PDF","dcterms:extent":"287 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-AYQNP0JO/b63219b7-86e5-477b-b753-5c308b9ea15e/TEXT","dcterms:extent":"18 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-AYQNP0JO","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"1997","dc:creator":["Došen, Danijel","Janušić, Renato","Krajina, Zdenko","Mršić-Krmpotić, Zrinka","Šmalcelj, Josip","Turić, Marko"],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:31"},{"@xml:lang":"sl","#text":"str. 181-185"}],"dc:identifier":["ISSN:1318-2099","COBISSID_HOST:7176921","URN:URN:NBN:SI:doc-AYQNP0JO"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Croatian Medical Association - Croatian Society of Radiology"},{"@xml:lang":"sl","#text":"Slovenian Medical Society - Section of Radiology"}],"dc:subject":[{"@xml:lang":"sl","#text":"Drug therapy"},{"@xml:lang":"sl","#text":"Nasopharyngeal neoplasms"},{"@xml:lang":"sl","#text":"Radiotherapy"},{"@xml:lang":"sl","#text":"Survival analysis"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Combined therapy of undifferentiated carcinoma of nasopharyngeal type|"},"dc:description":{"@xml:lang":"sl","#text":"From November 1989 to October 1993, 339 patients with stage IV undifferentiated carcinoma of nasopharyngeal type (UCNT) were enrolled in a randomized trial comparing neoadjuvant chemotherapy (cisplation, epirubicin, bleomycin - BEC) plus radiotherapy (171 patients) vs. radiotherapy alone (168 patients). All patient characteristics were well-balanced in both arms. The overall response rate assessed clinically by the investigator at the end of chemotherapy was 91% (WHO) with 47% CR and 4% PR. Three months after the completion of radiotherapy, a CR (clinical + CT scan) was observed in 55% of the combined treatment group compared to 34% in the radiotherapy-alone group (p<0.01). Tumor recurrence or progression was observed in 55/171 patients in the chemotherapy arm (32.7%), compared to 92/168 patients in the radiotherapy-alone arm (54.7%) (p<0.01). In conclusion, the addition of BEC type chemotherapy, has changed the proportion of UCNT patients continously disease free but the overall survival data are not yet mature"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-AYQNP0JO","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-AYQNP0JO"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-AYQNP0JO/8959bac6-cf27-449a-bccf-510e1562ebd3/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Onkološki inštitut Ljubljana"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-AYQNP0JO/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-AYQNP0JO"}}}}