{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BJ3UMSR5/8e4b6b25-bcad-4206-b551-f1223c241fb5/PDF","dcterms:extent":"3440 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-BJ3UMSR5/c637522c-236b-42cf-abf2-c4f25f223419/TEXT","dcterms:extent":"39 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-BJ3UMSR5","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2023","dc:creator":["Hrvatin Stančič, Bor","Liović, Mirjana","Sorčan, Tjaša","Zemljič Jokhadar, Špela"],"dc:contributor":"Liović, Mirjana","dc:format":[{"@xml:lang":"sl","#text":"številka:9/10"},{"@xml:lang":"sl","#text":"letnik:92"},{"@xml:lang":"sl","#text":"str. 427-434"}],"dc:identifier":["DOI:10.6016/ZdravVestn.3410","ISSN:1318-0347","COBISSID:176374275","URN:URN:NBN:SI:doc-BJ3UMSR5"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"bulozna epidermoliza"},{"@xml:lang":"sl","#text":"celične terapije"},{"@xml:lang":"en","#text":"cell therapies"},{"@xml:lang":"en","#text":"epidermolysis bullosa"},{"@xml:lang":"sl","#text":"iPS celice"},{"@xml:lang":"en","#text":"iPSC"},{"@xml:lang":"sl","#text":"koža"},{"@xml:lang":"en","#text":"skin"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Inducirane pluripotentne matične celice in možnosti njihove uporabe pri zdravljenju dednih bolezni kože| Induced pluripotent stem cells and their potential for the development of therapeutic approaches for hereditary skin disorders|"},"dc:description":[{"@xml:lang":"sl","#text":"In 1962, Gurdon discovered that cell specialization is reversible; he replaced the nucleus in a frog egg cell with a nucleus from an intestinal cell, and the altered egg cell developed into a tadpole. In 2006, Yamanaka discovered how by using just a few genes, adult mouse cells could be reprogrammed into a state similar to embryonic cells. The cells obtained in this way were called induced pluripotent stem cells, which can develop into all types of cells in the body, thus being a prom-ising tool for various treatment approaches based on cell therapies. Gurdon and Yamanaka won the 2012 Nobel Prize in Physiology for discovering mature cells’ potential to be reprogrammed into a pluripotent state. In this paper, we will briefly review findings in this field, emphasizing the group of rare hereditary diseases of skin fragility"},{"@xml:lang":"sl","#text":"Leta 1962 je Gurdon odkril, da je specializacija celic reverzibilna; jedro v jajčni celici žabe je nadomestil z jedrom iz čre-vesne celice. Iz spremenjene jajčne celice se je razvil paglavec. Leta 2006 je Yamanaka odkril, kako je mogoče z uporabo le nekaj genov reprogramirati odrasle mišje celice v stanje, ki je podobno embrionalnim celicam. Tako pridobljene celice so poimenovali inducirane pluripotentne matične celice, ki se lahko razvijejo v vse vrste celic v telesu, zato so obetavno orodje za različne pristope zdravljenja, ki temeljijo na celični terapiji. Gurdon in Yamanaka sta za odkritje, da je mogoče dozorele celice reprogramirati v pluripotentno stanje, leta 2012 prejela Nobelovo nagrado za fiziologijo. V tem prispevku bomo prikazali kratek pregled dognanj na tem področju, pri čemer bomo poudarili področje skupine redkih dednih bolez-ni krhkosti kože"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-BJ3UMSR5","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-BJ3UMSR5"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-BJ3UMSR5/8e4b6b25-bcad-4206-b551-f1223c241fb5/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-BJ3UMSR5/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-BJ3UMSR5"}}}}