{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-CKOCW4R2/108b0a4f-ec15-435c-8c60-08ce98f2cb08/PDF","dcterms:extent":"2221 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-CKOCW4R2/f1164256-c7f0-45f2-870c-547e1927c7b4/TEXT","dcterms:extent":"54 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-CKOCW4R2","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"1998","dc:creator":"Osmak, Maja","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:32"},{"@xml:lang":"sl","#text":"str. 19-33"}],"dc:identifier":["ISSN:1318-2099","COBISSID:7823065","URN:URN:NBN:SI:doc-CKOCW4R2"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Croatian Medical Association - Croatian Society of Radiology"},{"@xml:lang":"sl","#text":"Slovenian Medical Society - Section of Radiology"}],"dc:subject":[{"@xml:lang":"sl","#text":"Antineoplastic agents"},{"@xml:lang":"sl","#text":"citostatiki"},{"@xml:lang":"sl","#text":"Dna repair"},{"@xml:lang":"sl","#text":"Dna topoisomerase"},{"@xml:lang":"sl","#text":"Drug resistance"},{"@xml:lang":"sl","#text":"Drug resistance, neoplasm"},{"@xml:lang":"sl","#text":"Gene amplification"},{"@xml:lang":"sl","#text":"Glutathione"},{"@xml:lang":"sl","#text":"Glutathione peroxidase"},{"@xml:lang":"sl","#text":"Glutathione transferases"},{"@xml:lang":"sl","#text":"Metallothionein"},{"@xml:lang":"sl","#text":"molekularna biologija"},{"@xml:lang":"sl","#text":"odpornost"},{"@xml:lang":"sl","#text":"rak (medicina)"},{"@xml:lang":"sl","#text":"tumorske celice"},{"@xml:lang":"sl","#text":"zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Molecular alterations induced in drug-resistant cells|"},"dc:description":{"@xml:lang":"sl","#text":"The major obstacle to the ultimate success in cancer therapy is the ability oftumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/orbetter tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-CKOCW4R2","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-CKOCW4R2"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-CKOCW4R2/108b0a4f-ec15-435c-8c60-08ce98f2cb08/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Onkološki inštitut Ljubljana"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-CKOCW4R2/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-CKOCW4R2"}}}}