407 KB15 KB199220251999Čemažar, MajaFras, Albert-PeterRudolf, ZvonimirSerša, Gregorletnik:33številka:4str. 291-296COBISSID_HOST:11070937ISSN:1318-2099URN:URN:NBN:SI:doc-E28GH36OenCroatian Medical Association - Croatian Society of RadiologySlovenian Medical Society - Section of RadiologyRadiology and oncology (Ljubljana)CisplatinDrug delivery systemsDrug therapyElectroporationRadiotherapySecondarySkin neoplasmsTreatment outcomeAdenocarcinoma skin metastases treated by electrochemotherapy with cisplatin combined with radiation| Kombinirano zdravljenje kožnih metastaz adenocarcinoma z elektrokemoterapijo in obsevanjem|Background. The aim of this study was to determine the interaction between electrochemotherapy as a means of facilitated cisplatin delivery into the cells and irradiation of adenocarcinoma skin metastases. Case report. A patient with progressive disease presenting skin metastases of tubal dedifferentiated pappilary adenocarcinoma was enrolled in the study. Skin metastases were treated by electrochemotherapy with intratumoral injection of cisplatin. Its antitumor effectiveness was compared to that of combined treatment of irradiation with electrochemotherapy. After a two week observation time, the response to treatment was comparable between the electrochemotherapy and electrochemotherapy combined with irradiation. Both ofthese treatments were more effective than irradiation alone. Furthermore, antitumor effectiveness of the combined electrochemo- and radiotherapy was found to be quicker than that of electrochemotherapy alone. Comment. This study shows that electrochemotherapy with cisplatin is also effective in the treatment of adenocarcinoma skin metastases. Inspite of the short observation time, positive interaction between radiotherapy and electrochemotherapy with cisplatin was foundIzhodišča. Študijo smo opravili z namenom, da bi ugotovili medsebojni vpliv med elektrokemoterapijo, s katero smo pospešili vnos cisplatina v celice, in obsevanjem kožnih metastaz adenokarcinoma. Poročilo o primeru. Študija poroča o bolnici z napredovnajem bolezni in ugotovljenimi kožnimi metastazami tubularnega dediferenciranega papilarnega adenokarcinoma. Kožne metastaze smo zdravili z elektrokemoterapijo in vbrizgavanjem cisplatina v tumor. Učinek zdravljenja smo primerjali z učinkom kombiniranega zdravljenja z obsevanjem inelektrokemoterapijo. Obe metodi sta bili učinkovitejši od zdravljenja samo zobsevanjem. Ugotovili smo tudi, da je kombinirano zdravljenje z elektrokemoterapijo in radioterapijo hitreje učinkovalo na tumor kot zdravljenje samo s kemoterapijo. Zaključek. Študija potrjuje, da je elektrokemoterapija s cisplatinom uspešna tudi pri zdravljenju metastaz kožnega adenokarcinoma. Navzlic kratkemu opazovalnem času smo ugotovili ugodenmedsebojen vpliv radioterapije in elektrokemoterapije s cisplatinomTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaOnkološki inštitut Ljubljana