{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-HBN855ND/48d8916d-1460-4a82-85a7-c4a59ed8c06f/PDF","dcterms:extent":"286 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-HBN855ND/afb364e1-c329-45c3-a9cd-06f2a950703e/TEXT","dcterms:extent":"18 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-HBN855ND","edm:isNextInSequence":{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:doc-WC2RRVW3"},"dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"1999","dc:creator":"Nestle, Frank O.","dc:format":[{"@xml:lang":"sl","#text":"letnik:33"},{"@xml:lang":"sl","#text":"str. S64-8"},{"@xml:lang":"sl","#text":"številka:suppl. 1"}],"dc:identifier":["COBISSID_HOST:10734297","ISSN:1318-2099","URN:URN:NBN:SI:doc-HBN855ND"],"dc:language":"sl","dc:publisher":[{"@xml:lang":"sl","#text":"Croatian Medical Association - Croatian Society of Radiology"},{"@xml:lang":"sl","#text":"Slovenian Medical Society - Section of Radiology"}],"dc:subject":[{"@xml:lang":"sl","#text":"Cancer vaccines"},{"@xml:lang":"sl","#text":"Dendritic cells"},{"@xml:lang":"sl","#text":"Immunology"},{"@xml:lang":"sl","#text":"Melanoma"},{"@xml:lang":"sl","#text":"Skin neoplasms"},{"@xml:lang":"sl","#text":"Therapy"},{"@xml:lang":"sl","#text":"T-lymphocytes, cytotoxic"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Ocena rezultatov vakcinacije z dendritičnimi celicami pri zdravljenju raka priljudeh| Critical issues regarding dendritic cell vaccination for human cancer|"},"dc:description":[{"@xml:lang":"sl","#text":"Melanoma is an immunogenetic tumor with defined tumor antigens. An important therapeutic aim is the induction of anti-melanoma specific cytotoxic T-lymphocytes (CTL). Dendritic cells (DC) as natur's adjuvant have proven to be suitable for the inducation of anti-melanoma specific CTL in several murinemodels. We will discuss curent issues in the use of DC for treatment of human cancer such as the generation and application of human DC, use of surrogate helper antigens, various methods to detect antigen-specific immune response and briefly touch on some of our clinical data relating to vaccination of stage IV melanoma patients. Finally, we will propose reasons for missing response to DC therapy"},{"@xml:lang":"sl","#text":"Melanom je imunogeni tumor z znanimi tumorskimi antigeni. Pomemben terapevtskicilj je indukcija specifičnih T limpocitov (CTL) proti melanomu. Dendritične celice (DC) so se v večjih mišjih modelih pokazale kot primerne zaindukcjo specifičnih CTL proti melanomu. Razpravljali bomo o trenutnih rezultatih pri uporabi DC za zdravljenje raka pri ljudeh, kot je pridobivanje in uporaba humanih DC, uporaba nadomestnih helperskih antigenov, različnih metodah za odkrivanje za antigen specifičnih imunskih odzivov. Predstavili bomo tudi nekaj naših kliničnih ugotovitev, ki obravnavajo vakcinacijo bolnikov z melanomom v IV stadiju in razpravljli o vzrokih za neodzivnost na zdravljenje"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-HBN855ND","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-HBN855ND"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-HBN855ND/48d8916d-1460-4a82-85a7-c4a59ed8c06f/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Onkološki inštitut Ljubljana"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-HBN855ND/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-HBN855ND"}}}}