{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-IHIPMPCL/14388f36-6238-4349-884f-3d11275cb60d/PDF","dcterms:extent":"1926 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-IHIPMPCL/a71b6449-b063-463a-bd28-2fa4b0996dbd/TEXT","dcterms:extent":"55 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-IHIPMPCL","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2023","dc:creator":["Dreu, Rok","Zorec, Barbara"],"dc:format":[{"@xml:lang":"sl","#text":"letnik:92"},{"@xml:lang":"sl","#text":"številka:iss. 5-6"},{"@xml:lang":"sl","#text":"str. 221-232"}],"dc:identifier":["DOI:10.6016/ZdravVestn.3347","COBISSID_HOST:146228739","ISSN:1581-0224","URN:URN:NBN:SI:doc-IHIPMPCL"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"biocompatible printing substrates"},{"@xml:lang":"sl","#text":"biokompatibilne podlage za tiskanje"},{"@xml:lang":"sl","#text":"brizgalni tiskalnik"},{"@xml:lang":"sl","#text":"črnila za tiskanje"},{"@xml:lang":"sl","#text":"disperzije nanodelcev"},{"@xml:lang":"sl","#text":"Farmacija"},{"@xml:lang":"en","#text":"ink for 2D printing"},{"@xml:lang":"en","#text":"inkjet printer"},{"@xml:lang":"en","#text":"nanoparticle dispersion"},{"@xml:lang":"en","#text":"personalized therapy"},{"@xml:lang":"sl","#text":"Personalizirana medicina"},{"@xml:lang":"sl","#text":"personalizirano zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Nanos zdravilnih učinkovin na biokompatibilne podlage z metodo 2D tiskanja za izdelavo farmacevtskih oblik, prilagojenih bolnikom| Deposition of drugs on biocompatible substrates using the 2D printing method for the preparation of personalized dosage forms|"},"dc:description":[{"@xml:lang":"sl","#text":"The importance of personalized treatment is drastically growing since the awareness of people’s diversity, especially of the diversity of their organisms, is increasing every year. Discoveries in genetics and their influence on the develop-ment of some diseases confirm the value of such treatment. Therefore, current research in pharmaceutical technology is increasingly leaning towards developing and optimizing dosage forms suitable for it. In this regard, more and more re-searchers are focusing on the development of 2D printing technology. Its convenience, the possibility of its extensive use, and the possibility for simple drug concertation adjustment are bringing this technology to the forefront. The drug inject printing principle is the same as printing text documents, yet the ink is replaced by drug dispersion, while paper sheets are replaced by various biocompatible substrates that serve as oral dosage forms. For this purpose, different types of printers meeting different specifications can be used to print drugs successfully. The advantages of such technology are the rapid production of personalized medicine and the ability to combine several different drugs simultaneously in a single dosage form. Despite all the advantages of printing technology, there are still some challenges that must be addressed before such a drug delivery system will reach the market and be available to patients"},{"@xml:lang":"sl","#text":"Pomen personaliziranega načina zdravljenja se iz leta v leto povečuje, saj je zavedanje, da ljudje nismo popolnoma enaki in da vsak organizem potrebuje sebi lastno terapijo, vedno večje. Poznavanje genetike in njenega vpliva na izvor in po-tek nekaterih bolezni pomen personaliziranega zdravljenja še povečuje. Zato se trenutne raziskave v farmacevtski stroki vedno bolj nagibajo k razvoju in optimizaciji zdravil, ki bi omogočala tak način zdravljenja. V ta namen je dandanes vedno več raziskovalcev, usmerjenih v razvoj nanosa zdravilnih učinkovin (ZU) na podlage z metodo 2D tiskanja, ki zaradi svoje priročnosti, možnosti široke uporabe in enostavnega prilagajanja odmerkov iz dneva v dan pridobiva na vrednosti. Princip tiskanja poteka na enak način kot tiskanje besedilnih dokumentov, le da črnila zamenjamo z disperzijo ZU, medtem ko namesto listov papirja uporabimo različne biološko kompatibilne podlage, ki skupaj z natisnjeno zdravilno učinkovino služijo kot per oralna farmacevtska oblika. Pri tiskanju ZU lahko uporabimo različne vrste tiskalnikov, pri čemer pa vsak izmed njih za uspešno tiskanje zahteva izpolnitev določenih specifikacijskih zahtev. Prednosti, ki jih nanos ZU z metodo 2D tiskanja prinaša, so poleg hitre izdelave personalizirane farmacevtske oblike (FO) z natančnim odmerjanjem tudi hkratno tiskanje in s tem združevanje več ZU hkrati v eno samo FO. Kljub vsemu omenjenemu pa na tem področju še vedno obstaja veliko izzivov, s katerimi se bo potrebno spopasti, preden bo tak način izdelave in odmerjanja zdravil dosegel trg in bil na voljo pacientom"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-IHIPMPCL","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-IHIPMPCL"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-IHIPMPCL/14388f36-6238-4349-884f-3d11275cb60d/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-IHIPMPCL/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-IHIPMPCL"}}}}