{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITWHR7XZ/665f4e44-20c9-4b04-9a3a-f61b93352f7c/HTML","dcterms:extent":"19 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITWHR7XZ/fbe3c212-5764-4d1d-91f0-3401287748f5/PDF","dcterms:extent":"72 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITWHR7XZ/71d8b80a-e9ef-4778-8094-2e15d64ac35d/TEXT","dcterms:extent":"18 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-ITWHR7XZ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2002","dc:creator":["Gaberšček, Simona","Hojker, Sergej"],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:71"},{"@xml:lang":"sl","#text":"str. 101-103"}],"dc:identifier":["ISSN:1318-0347","COBISSID:14508505","URN:URN:NBN:SI:doc-ITWHR7XZ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"Avtoimunski tiroiditis"},{"@xml:lang":"sl","#text":"endokrinologija"},{"@xml:lang":"en","#text":"Goiter"},{"@xml:lang":"sl","#text":"Golša"},{"@xml:lang":"en","#text":"Graves' disease"},{"@xml:lang":"sl","#text":"Gravesova bolezen"},{"@xml:lang":"sl","#text":"Kajenje"},{"@xml:lang":"en","#text":"Smoking"},{"@xml:lang":"sl","#text":"ščitnica"},{"@xml:lang":"sl","#text":"škodljivost"},{"@xml:lang":"en","#text":"Thyroiditis, autoimmune"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv kajenja na ščitnico| Influence of cigarette smoking on thyoid gland|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Serum thiocyanate concentrations are higher in smokers than in nonsmokers. Thiocyanate inhibits iodide uptake and organification of iodine and increases iodide efflux from the thyroide cell in vitro. In jodine-deficient areas the incidence of goiter among smokers is increased. Smokers have higer prevalence of Graves disease. There is an evenstronger relationship between smoking, and prevalence and degree of endocrine ophthalmopathy. Possible causes are direct irritative effect of cigarette smoke and stimulation of immune reactions. Smoking ameliorates clinical and metabolic effects of hypothyroidism in patients with Hashimoto thyroiditis. Conclusions. Thyroid should be added to the growing list of organs negatively influenced by cigarette smoking. In the iodine-deficient areas possible goitrogenic effect of smoking should be considered (Slovenia is a mild iodine-deficient area). Patients with endocrine ophthalmopathy should be encouraged to refrain from smoking"},{"@xml:lang":"sl","#text":"Izhodišča. Kadilci imajo v serumu višjo koncentracijo tiocianata od nekadilcev. Tiocianat zavira kopičenje jodida in njegovo organifikacijo ter poveča izstop jodida iz ščitnične celice in vitro. Na področju pomanjkanja joda v prehrani je pogostnost pojava golše pri kadilcih povečana. Pri kadilcihje večja tudi prevalenca bazedovke. Kajenje je še močneje povezano s prevalenco in težo endokrine oftalmopatije. Možna vzroka sta iritativno delovanje cigaretnega dima in stimulacija imunskega dogajanja. Kajenje poslabša tudi klinične in biokemične manifestacije hipotiroze pri bolnikih s tiroiditisom Hashimoto. Zaključki. Tudi ščitnico je treba uvrstiti na obsežen seznam organov, na katere škodljivo vpliva kajenje. Kajenje poveča pojav golšezlasti na področjih pomanjkanja joda v prehrani (Slovenija je področje blagega pomanjkanja joda). Bolnikom z endokrino oftalmopatijo moramo odsvetovati kajenje"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-ITWHR7XZ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-ITWHR7XZ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-ITWHR7XZ/fbe3c212-5764-4d1d-91f0-3401287748f5/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-ITWHR7XZ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-ITWHR7XZ"}}}}