34 KB274 KB30 KB199220252005Cerar, AntonPerše, Martinaštevilka:110 straniletnik:39str. 61-70ISSN:1318-2099COBISSID:19252953URN:URN:NBN:SI:doc-MIQ6U2LXenAssociation of Radiology and OncologyRadiology and oncology (Ljubljana)AdenocarcinomaAdenokarcinomAdenomAdenomaBolezen, živalski modeliChemically InducedColorectal NeoplasmsčrevesjeDimethylhydrazinesDimetilhidraziniDisease Models, AnimalKolorektalne novotvorbeMiši seva F344PathologypodganePodgane, Sprague-DawleyPodgane, Wistarposkusirak (medicina)Rats, Inbred F344Rats, Sprague-DawleyRats, WistarThe dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis|Animal models of colorectal carcinogenesis represent invaluable research tool for investigating colorectal cancer (CRC). Experimentally induced tumours in laboratory animals provide opportunity for studying certain aspects of tumoursthat cannot be effectively studied in humans. Significant information on human CRC aetiology or factors influencing it has derived from studies using dimethylhydrazine (DMH) model that is one of the experimental models appreciated for its morphological similarity to human CRC. Today, DMH model represents useful research tool for the studies of colon carcinogens and chemopreventive agents. The review offers insight into morphogenesis and genetic alterations of DMH induced colorectal epithelial tumours in ratsŽivalski modeli so pri raziskavah raka na debelem črevesju in danki nepogrešljivi, saj omogočajo raziskovanje in testiranje številnih dejavnikov, ki jih ni mogoče neposredno ugotavljati pri ljudeh. Edinega izmed živalskih modelov raka na debelem črevesju in danki predstavljajo z dimetilhidrazinom (DMH) inducirane podgane, ki razvijejo tumorje debelega črevesa in danke zelo podobne humanim. S člankom želimo predstaviti morfološke in genetske spremembetega modela, ki je veliko prispeval k današnjemu poznavanju etioloških in drugih dejavnikov, ki vplivajo na nastanek in razvoj raka. Danespa je nepogrešljiv pri raziskavah črevesnih karcinogenov in kemopreventivnih substancTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo radiologije in onkologije