{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-MQNCPMK9/9631ee62-9472-43f5-868b-16b66045ea14/HTML","dcterms:extent":"26 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-MQNCPMK9/8ed87d92-8fd8-4520-8bd8-56df1595a43e/PDF","dcterms:extent":"123 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-MQNCPMK9/a4ed8103-01b3-4c60-afee-221c9c4c288a/TEXT","dcterms:extent":"24 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-MQNCPMK9","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2003","dc:creator":"Milisav, Irina","dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:72"},{"@xml:lang":"sl","#text":"str. 85-89"}],"dc:identifier":["ISSN:1318-0347","COBISSID:15957465","URN:URN:NBN:SI:doc-MQNCPMK9"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"Gene Therapy"},{"@xml:lang":"en","#text":"Genetic Vectors"},{"@xml:lang":"sl","#text":"Genetski vektorji"},{"@xml:lang":"sl","#text":"gensko inženirstvo"},{"@xml:lang":"sl","#text":"Gensko zdravljenje"},{"@xml:lang":"en","#text":"Neoplasms"},{"@xml:lang":"sl","#text":"Novotvorbe"},{"@xml:lang":"en","#text":"Oligonucleotides, Antisense"},{"@xml:lang":"sl","#text":"Oligonukleotidi protismerni"},{"@xml:lang":"en","#text":"Plasmids"},{"@xml:lang":"sl","#text":"Plazmidi"},{"@xml:lang":"en","#text":"Therapy"},{"@xml:lang":"en","#text":"tumor"},{"@xml:lang":"sl","#text":"zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Zdravljenje z gensko terapijo| Gene therapy|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Gene therapy is a novel approach to treat, cure, or ultimately prevent disease by changing the expression of person's genes. Gene therapy is in its inflancy, and current gene therapy is primarily experimental, with mosthuman clinical trials only in the research stages. There were 600 studies initiated from 1990-2002, mostly in USA. Conclusions. Most of the gene therapyprotocols currently tested are for treating various cancers. This is followed by the treatment of cardiovascular diseases, genetic diseases and infectious diseases, the latter mostly to control the HIV infection. About 5 studies devoted to cancer treatment are in the third phase of the trials and may be approved for clinical use in the near future"},{"@xml:lang":"sl","#text":"Izhodišča. Genska terapija ali gensko zdravljenje je zdravstveni poseg, pri katerem se vnese genetski material (nukleinske kisline) za nadomestilo, spremembo ali utišanje izražanja genov. Z nadomestilom ali z uravnavanjem okvarjenega gena bi želeli odpraviti vzroke bolezni. Od prvih kliničnih poskusov, ki so se začeli leta 1990, do septembra 2001 je bilo po svetu začetih že približno 600 kliničnih študij, največ v ZDA. Do danes še ni bil odobren način zdravljenja, ki bi temeljil na tehnikah genske terapije, vendar je približno pet študij v zadnjih fazah kliničnih poskusov. Zaključki. Trenutno so najbolj razvite metode za zdravljenje nekaterih malignih tumorjev.Poleg tega poskušajo gensko terapijo razviti še za zdravljenje bolezni srca in žilja, genetskih bolezni in okužb z virusi, predvsem s HIV. Obugodnih rezultatih se bodo ti postopki v nekaj letih začeli uporabljati v klinični praksi"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-MQNCPMK9","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-MQNCPMK9"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-MQNCPMK9/8ed87d92-8fd8-4520-8bd8-56df1595a43e/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-MQNCPMK9/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-MQNCPMK9"}}}}