{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-OIUPUUYY/753de768-e4df-4078-8570-ee9aa7e67b76/HTML","dcterms:extent":"16 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-OIUPUUYY/f336e4fe-6685-4ea1-9805-e0849264281a/PDF","dcterms:extent":"70 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-OIUPUUYY/b8080976-7539-4e2b-87e4-941a2e6c9648/TEXT","dcterms:extent":"15 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-OIUPUUYY","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2009","dc:creator":"Lukanovič, Adolf","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:78"},{"@xml:lang":"sl","#text":"str. I-123-I-125"}],"dc:identifier":["ISSN:1318-0347","COBISSID:15393881","URN:URN:NBN:SI:doc-OIUPUUYY"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"matične celice"},{"@xml:lang":"sl","#text":"rekonstrukcija"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"urinska inkontinenca"},{"@xml:lang":"sl","#text":"zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Zdravljenje stresne urinske inkontinence z matičnimi celicami - vizija prihodnosti?| Stem cells in the treatment of urinary stress incontinence - a vision of future?|"},"dc:description":[{"@xml:lang":"sl","#text":"For one third of all women urinary incontinence is a health problem. Different strategies of treatment have been used, namely surgical, medical and physiotherapy. To this armamentarium a new method - adult stem cells therapy -has been added. The source of adult autologues multipotent stem cells consists of muscle-derived stem cells, adipose-derived stem cells and mesenchymed bone marrow cells. In facilities for stem cells with processing and in the presence of specific inducing factors, muscle derived stem cells can be differentiated to striated or smooth muscles. Clinical work is based on animal models that with immunohistochemical analysis demonstrated new skeletal-muscle fiber formation at the site of injection of stem cells. In stress urinary incontinence (SUI) autologues bioptic material is obtained by using a musle needle biopsy device. From the biopsy speciment with dissociation muscle-derived stem cells are isolated and injected under local anaesthesia in the middle urethra and/or external urethral sphincter. Initial results of SUI treatment with adult muscle-derived stem cells suggest that perspectives of this method are encouraging. Stem cell therapy is promising to become minimally invasive method for reconstruction of the muscles and connective tissue of urethra and external urethral sphincter"},{"@xml:lang":"sl","#text":"Urinska inkontinenca je zdravstveni problem tretjine vseh žensk. V zdravljenju so se doslej uveljavili kirurški postopki, različna zdravila in fizioterapija. Naboru teh metod pa se je pridružila tudi nova - uporaba matičnih celic odraslega organizma. Matične celice lahko pri odraslem organizmu pridobimo iz progastih mišic, maščobnega tkiva ali iz mezenhimskih celic kostnega mozga. V laboratorijskih pogojih se pod vplivom različnih induktorjev razvijejo v normalno delujoče gladke ali progaste mišice. Klinično delo temelji na dokazih iz poskusov na živalih, ko so imunohistokemično dokazali novonastala mišična vlakna na mestu vnosa matičnih celic. Kot vir matičnih celic se pri zdravljenju stresne urinske inkontinence (SUI) uporablja bioptični material mišic nadlahti. S procesiranjem bioptičnega vzorca se diferencirajo matične celice, ki izvirajo iz mišic in se v lokalni anesteziji uvedejo v srednji del uretre in zunanji sfinkter uretre. Prvi rezultati zdravljenja SUI z vnosom matičnih celic, diferenciranih iz avtolognih mišic, kažejo na dobre razvojne perspektive tega področja. Zdravljenje z matičnimi celicami obeta, da bo postalo minimalna invazivna metoda za rekonstrukcijo mišic in vezivnega tkiva uretre in zunanjega uretralnega sfinktra"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-OIUPUUYY","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-OIUPUUYY"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-OIUPUUYY/f336e4fe-6685-4ea1-9805-e0849264281a/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-OIUPUUYY/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-OIUPUUYY"}}}}