1027 KB0 KB192920262020Berlot, RokGrmek, MarkoJamšek, JanRus, TomažŠurlan Popović, KatarinaTrošt, Majaštevilka:3/4letnik:89str. 203-222ISSN:1318-0347COBISSID_HOST:34798297URN:URN:NBN:SI:doc-OKDJUPU5slSlovensko zdravniško društvoZdravniški vestnikbrain metabolismdopamine transporter scintigraphymetabolizem možganovneurodegenerative disordersnevrodegenerativne bolezniscintigrafija dopaminskega prenašalcaNuklearnomedicinske preiskave pri diagnosticiranju demence in parkinsonizmov| Nuclear medicine investigations in dementia and parkinsonism|The incidence of neurodegenerative brain disorders presenting as dementia or parkinsonism is increasing with aging population. Early and correct diagnosis is essential for the exclusion of potentially curable causes, to optimize symptomatic treatment, social care and to select patients for clinical trials. Final diagnosis of most neurodegenerative brain diseases can only be made at pathohistological examination of the brain tissue. However, functional nuclear-medicine investigations contribute greatly to the diagnosis in vivo. Changes in regional brain metabolism, neurotransmitter system dysfunction and misfolded protein deposition can be observed. Based on specific changes in regional brain metabolism measured with 18F-FDG PET we can distinguish between Alzheimer's disease, dementia with Lewy body and frontotemporal dementia and between Parkinson's disease and other neurodegenerative parkinsonisms. Dopaminergic system imaging (e.g. dopamine transporter scintigraphy, DaTSCAN) enables us to discriminate neurodegenerative parkinsonism from alternative causes. Excessive deposition of amyloid-beta, a pathological hallmark of Alzheime's disease, can be identified with amyloid PET already in preclinical subjects. Nuclear medicine imaging methods, indications, characteristic findings and limitations of these investigations in neurodegenerative brain disorders are presented in this articleTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo