{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ONBO2MRT/309f07a2-897a-4d7f-91b6-786e82e6c142/HTML","dcterms:extent":"63 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ONBO2MRT/bbf766ac-d62b-4611-aa2f-0d03d0258637/PDF","dcterms:extent":"667 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-ONBO2MRT/889b3b84-84bd-4d54-9fe9-006fbda854b6/TEXT","dcterms:extent":"56 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-ONBO2MRT","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2005","dc:creator":"Ščuka, Leon","dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:74"},{"@xml:lang":"sl","#text":"str. 39-48"}],"dc:identifier":["ISSN:1318-0347","COBISSID:1685617","URN:URN:NBN:SI:doc-ONBO2MRT"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"medicina"},{"@xml:lang":"en","#text":"medicine"},{"@xml:lang":"sl","#text":"metaanaliza"},{"@xml:lang":"sl","#text":"metodologija"},{"@xml:lang":"sl","#text":"sistematični pregledi"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Pomen metaanalize v medicini| Meta-analysis in medicine|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Meta-analysis is a process of using statistical methods to review and combine the results of different, independent clinical studies. Glass first used the term meta-analysis in 1976, when he and his co-worker Mary Lee Smith statistically combined the results of 375 studies that evaluated the efficacy of psychotherapy. Meta-analysis is of particular importance in the assessment of therapeutic efficacy as individual studies do not provide an overview over a topic in its entirety. As their samples are too small, individual studies cannot provide a quantitative evaluation of the effect of treatment, nor can they test the null hypothesis. Prior to meta-analysis, the traditional method was a narrative discourse on previous findings, which, however, could be misleading and subjective. In the past few years, meta-analysis has been increasingly used in all fields of science. This is particularly evident in the medical science, where two other terms are used aswell - the systematic review and evidence based medicine. Other methods thathave advanced markedly are the decision analysis and cost- effectiveness analysis. All these methods are connected, and the latter two are an upgrade of the first two. Systematic reviews are exact summaries of the best evidence related to exactly specified clinical dilemmas. Special centres, like the Cochrane Collaboration have been organised in different places around the world, where systematic reviews of scientific literature and their own findings are published in databases collecting data on most appropriate therapies of individual illnesses. These reviews support the synthesis of bestevidence for treatment or establishment of best medical practices. In this case, meta-analysis has a broader impact and is not just a statistical method for collecting study results. Conclusions. In addition to reviewing andcombining results, meta-analysis also offers an upgrade option for discovering and exploring differences in the existing scientific literature inthe research field of interest and may provide the most plausible explanations or even result in the discovery of new knowledge. If well performed, meta-analysis can give practical answers to contraversal clinical issues and save costs of additional clinical experiments"},{"@xml:lang":"sl","#text":"Izhodisea. Metaanaliza je metoda pregledovanja in kombiniranja rezultatov vee neodvisnih klinienih raziskav. Poimenovanje metaanaliza je prvi uporabil Glass leta 1976, ko je s sodelavko Mary Lee Smith statistieno zdruzil rezultate 375 studij, ki so obravnavale ueinkovitost psihoterapije. Metaanaliza ima poseben pomen pri potrjevanju ueinkovitosti zdravljenja, ker posamezne studije ne omogoeajo pregleda nad celotno obravnavano problematiko. Po navadi imajo tudi premajhne vzorce, zato ne morejo kvantitativno opredeliti, kaksen je vpliv zdravljenja, niti testirati nieelne hipoteze. Pred obdobjem metaanalize so pripovedno primerjali rezultate studij, kar pa je bilo lahko zavajajoee in subjektivno.V zadnjih letih lahko opazimo poveean obseg opravljenih metaanaliz v vseh vejah znanosti. To se posebej velja za medicino, kjer sta poleg pojma metaanaliza v uporabi se poimenovanji sistematieni pregled strokovne literature (systematic review) in na izsledkih temeljeea medicina (evidence based medicine). V medicini sta moeno napredovali tudi analiza odloeanja (decision analysis) ter analiza stroskov in ueinkovitosti (cost-effectiveness analysis). Vse nastete metode so medsebojno povezane, zadnji dve pa sta nekaksna nadgradnja prejsnjih.Sistematieni pregledi so nataneni povzetki najboljsih dokazov, ki se nanasajo na nataneno doloeena kliniena vprasanja. Ustanovili so posebne centre, npr. Kohranova sredisea po vsem svetu, ki opravljajo sistematiene preglede strokovne literature in objavljajo svoje izsledke v bazah, ki hranijo podatke o najprimernejsem zdravljenju doloeenih bolezni. Torej so v pomoe pri sintezi najboljsih dokazov za zdravljenje oz. vzpostavljanje najboljse zdravniske prakse. Lahko reeemo, da gre za metaanalizo v sirsem smislu, saj jo sicer definirajo samo kot statistieno metodo zdruzevanja rezultatov studij.Zakljueki. Metaanaliza poleg samega pregledovanja in kombiniranja izsledkov ponuja tudi nadgradnjo v smislu odkrivanja in proueevanja razlik v dosegljivi znanstveni materiji ter doseganju ali vsaj ponujanju najbolj verjetnih razlag ter celo odkrivanju novih spoznanj.Pravilno izvedena metaanaliza lahko zagotovi praktiene odgovore na protislovna kliniena vprasanja, uspesno izvedena pa prihrani stroske za dodatne kliniene poskuse"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-ONBO2MRT","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-ONBO2MRT"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-ONBO2MRT/bbf766ac-d62b-4611-aa2f-0d03d0258637/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-ONBO2MRT/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-ONBO2MRT"}}}}