70 KB20 KB192920262004Bevc, SebastjanDajčman, DavorinEkart, RobertHojs, Radovanštevilka:4letnik:73str. 177-179ISSN:1318-0347COBISSID_HOST:1521983URN:URN:NBN:SI:doc-OVK2OYSJslSlovensko zdravniško društvoZdravniški vestnikAmiloidozaAmyloidosisCrohn diseaseCrohnova bolezenNefrotični sindromNephrotic syndromeProteinuriaProteinurijaSekundarna amiloidoza ob Crohnovi bolezni ter nefrotični sindrom: prikaz primera| Secondary amyloidosis with Crohn's disease and nephrotic syndrome: case report|Background. Amyloidosis is a group of diseases, for which the extracellular deposition of fibrillary protein, called amyloid, is typical. There are many kinds of amyloidoses. Secondary amyloidosis is connected with previously existing inflammatory disorders which also include the Crohn's disease. The kidneys are important target organs. Proteinuria is usually the first sign of deposition of the amyloid in the kidneys. The nephrotic syndrome is important for the prognosis of the disease. The treatment of the secondary amyloidosis is limited to colhicin therapy and treatment of basic inflammatory process and its complications. Patients and methods. The 67 years old female was accepted in hospital because of uncontrolled high blood pressure, microcyte anemia, high levels of serum creatinine and urea. Nephrotic syndrome was present. Kidney biopsy showed a secondary amyloidosis. Colonoscopy showed the signs of Crohn's disease of rectosigma. The patient was treated with antihypertonic therapy, hydrocortisone enemas and mesalazine. Conclusions. A rare form of secondary amyloidosis connected with Crohn's disease was presented that had caused the nephrotic syndrome and renal failureIzhodišča. Amiloidoza so raznovrstne skupine bolezni, za katere je značilno zunajcelično odlaganje fibrilarne beljakovine, imenovane amiloid. Poznamo več vrst amiloidoz. Sekundarna amiloidoza je povezana z dosedanjimi vnetnimi procesi, med katere sodi tudi Crohnova bolezen. Za bolezenski proces sta ledvici pomemben tarčni organ. Proteinurija je največkrat prvi znak nalaganja amiloida v ledvicah, nefrotični sindrom pa je pomemben za napoved izida bolezni. Zdravljenje sekundarne amiloidoze je omejeno na kolhicin in zdravljenje osnovnega vnetnega procesa ter njegovih zapletov. Bolniki in metode. Avtorji so prikazali 67-letno bolnico, ki je bila zdravljena zaradi neurejene arterijske hipertenzije, mikrocitne anemije, visokih vrednosti dušičnih retentov in proteinurije. Ugotavljali so prisotnost nefrotičnega sindroma. Patohistološki in imunofluorescenčni izsledek ledvične biopsije je ustrezal diagnozi sekundarne amiloidoze. Koloskopija je pokazala znake Crohnove bolezni rektosigme. Bolnica je prejemala večtirno antihipertenzivno zdravljenje, mesalazin in hidrokortizonske klizme. Zaključki. Predstavili smo primer redke oblike sekundarne amiloidoze, povezane s Crohnovo boleznijo, ki je povzročila nefrotični sindrom in ledvično odpovedTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo