1580 KB16 KB199220251998Mäder, Karstenštevilka:1letnik:32str. 89-94ISSN:1318-2099COBISSID_HOST:7652825URN:URN:NBN:SI:doc-P8SOURF0enCroatian Medical Association - Croatian Society of RadiologySlovenian Medical Society - Section of RadiologyRadiology and oncology (Ljubljana)Antineoplastic agentsBiodegradationDrug carriersDrug delivery systemsElectron spin resonance spectroscopyMagnetic resonance imagingMonitoring drug release and polymer erosion from therapeutically used biodegradable drug carriers by EPR and MRI in vitro and in vivo| Ugotavljanje sproščanja zdravil in erozije polimerov s tehnikami EPR in MRI izbiološko razgradljivih prenašalcev zdravil|The in vivo performance of anticancer drugs is very often limited by their poor bioavailability, serious side effects and short half lives. During the last years, biodegradable drug carriers have been developed to overcome these problems. Despite the clinical use of these delivery systems, there is a rather poor understanding of the detailed mechanisms of drug realse and polymer erosion, particularly in vivo. The paper demonstrates how nonivasive magnetic resonance techniques ESR and MRI may contribute to increase our understanding of the in vivo fate of biodegradable drug delivery systemsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaOnkološki inštitut Ljubljana