{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-R26WENTC/fb7ab89e-73cf-4683-a730-90ebe14f5097/HTML","dcterms:extent":"34 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-R26WENTC/984318a7-721f-4c72-bc2d-2502b7a3a221/PDF","dcterms:extent":"473 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-R26WENTC/31b2c841-6cdf-4b54-95ba-9309cfa741e9/TEXT","dcterms:extent":"30 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-R26WENTC","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2010","dc:creator":["Čufer, Tanja","Ovčariček, Tanja","Sadikov, Aleksander","Triller, Nadja"],"dc:format":[{"@xml:lang":"sl","#text":"številka:10"},{"@xml:lang":"sl","#text":"letnik:79"},{"@xml:lang":"sl","#text":"8 strani"},{"@xml:lang":"sl","#text":"str. 669-676"}],"dc:identifier":["ISSN:1318-0347","COBISSID:27496409","URN:URN:NBN:SI:doc-R26WENTC"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"Carcinoma, Non-Small-Cell Lung"},{"@xml:lang":"en","#text":"C-Reactive Protein"},{"@xml:lang":"sl","#text":"C-reaktivna beljakovina"},{"@xml:lang":"sl","#text":"C-reaktivni protein"},{"@xml:lang":"en","#text":"Drug Therapy"},{"@xml:lang":"sl","#text":"hemoglobin"},{"@xml:lang":"sl","#text":"Hemoglobini"},{"@xml:lang":"en","#text":"Hemoglobins"},{"@xml:lang":"sl","#text":"Karcinom nemalocelični, pljučni"},{"@xml:lang":"en","#text":"Lung Neoplasms"},{"@xml:lang":"sl","#text":"Pljučne novotvorbe"},{"@xml:lang":"sl","#text":"pljučni rak"},{"@xml:lang":"sl","#text":"preživetje"},{"@xml:lang":"sl","#text":"Preživetje, analiza"},{"@xml:lang":"sl","#text":"prognoza"},{"@xml:lang":"en","#text":"Retrospective Studies"},{"@xml:lang":"sl","#text":"Retrospektivne študije"},{"@xml:lang":"en","#text":"Survival Analysis"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Prognostic value of C-reactive protein and other classical factors in patients with advanced non-small cell lung carcinoma treated in routine clinical practice| Napovedna vrednost C-reaktivnega proteina in drugih dejavnikov pri bolnikih z napredovalim nedrobnoceličnim karcinomom pljuč zdravljenih rutinsko v klinični praksi| Napovedna vrednost C-reaktivnega proteina in drugih dejavnikov pri bolnikih z napredovalim nedrobnoceličnim karcinomom pljuč zdravljenih rutinsko v klinični praksi|"},"dc:description":{"@xml:lang":"sl","#text":"Background: Prognostic factors may help the clinician in treatment decision making. The significance of C-reactive protein (CRP) as a negative prognostic factor has been shown in patients with different malignancies. However, only few studies have analyzed CRP as a prognostic factor in patients with advancednon-small cell lung cancer (NCLCS). The aim of this study was to evaluate the prognostic value of CRP and other prognostic factors in a group of unselected population of patients with advanced NCLSC treated with platinumbased chemotherapy. Methods: The retrospective study was conducted by reviewing 53 medical files of advanced NSCLC patients treated with platinum/gemcitabine at the University Clinic Golnik between May 2004 and November 2008. The median age of patients was 65 years, most of them were males (75 %), smokers or ex-smokers (81 %), with performance status 1 ( 64.2 %) and stage IV disease (83 %). The collected data included laboratory characteristics (Hb, platelet count, CRP, LDH) before chemotherapy, information on each individual patientćs therapy and outcome. The median number of chemotherapy cycles received was 4 (range, 1-6). Results: The medianprogression free survival (PFS) for the entire group was 4.8 months (range 0.20 months). Patients with elevated CRP levels (. 20 mg/l) had inferior PFS compared to those with low pretreatment CRP values (median PFS 8.4 vs 3.6 months, p=0.006). In Cox univariate regression analysis, CRP (p=0.016, HR=1.008, 95 %CI, 1.001.1.014), Hb (p=0.001, HR= 0.96, 95 %CI, 0.95.0.99), and comorbidity (p=0.051, HR=1.2, 95 %CI, 1.00 -1.45) were found to be significant prognostic factors; age, LDH, and platelet count on the other hand were not found to be significant prognostic factors. In multivariate analysis only CRP (p=0.048, HR=0.50, 95 %CI 0.26.0.99) and Hb (p=0.005, HR=0.97, 95 %CI, 0.95 -0.99) retained their independent prognostic value. (Abstract truncated at 2000 characters)"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-R26WENTC","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-R26WENTC"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-R26WENTC/984318a7-721f-4c72-bc2d-2502b7a3a221/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-R26WENTC/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-R26WENTC"}}}}