38 KB435 KB33 KB192920262011Čeh, MarijaFikfak, NatašaKrstanoska, FrosinaPreložnik-Zupan, IrenaUmek Bricman, Irenaštevilka:5letnik:80str. 413-421ISSN:1318-0347COBISSID:28448473URN:URN:NBN:SI:doc-RIER6M8LslSlovensko zdravniško društvoZdravniški vestnikkronična mieloična levkemijalevkemijaneželeni učinkitherapyzaviralci tirozinske kinazezdravljenjeResni neželeni učinki zdravljenja kronične levkemije z zaviralci tirozinske kinaze| case reports and literature review| prikaz primerov in pregled literature| Severe adverse effects associated with tyrosine kinase inhibitors therapy in chronic myeloid leukaemia|Background: Chronic myeloid leukaemia is a clonal myeloproliferative disorder of myeloid progenitor cells. The availability of moleculartargeted therapy with tyrosine kinase inhibitors has changed the course and treatment for patients with chronic myeloid leukemia. The long-term follow-up of adverse events amongst the kinase inhibitors played role in forming decision- making algorithms for the use of this highly effective group of therapeutics. Patients and methods: In this paper, four CML patients are presented, treated with different tyrosine kinase inhibitors. Haematologic toxicity of kinase inhibitors is the most frequent adverse effect; however, non-haematological adverse effects should also not be neglected. Conclusions: Tyrosine kinase inhibitors have changed the therapy of CML, the treatment of these patients isa long-term process. Therefore, to know adverse effects is the matter of great importance in order to promptly recognise them and treat them properlyTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo