{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-RIER6M8L/1081b8f1-24c2-4b50-9676-3451f4808d60/HTML","dcterms:extent":"38 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-RIER6M8L/8158dc5a-5324-41b3-9e1b-450d527ff012/PDF","dcterms:extent":"435 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-RIER6M8L/71f55cac-2114-48e5-aba3-1ede2b0ebd21/TEXT","dcterms:extent":"33 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-RIER6M8L","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2011","dc:creator":["Čeh, Marija","Fikfak, Nataša","Krstanoska, Frosina","Preložnik-Zupan, Irena","Umek Bricman, Irena"],"dc:format":[{"@xml:lang":"sl","#text":"številka:5"},{"@xml:lang":"sl","#text":"letnik:80"},{"@xml:lang":"sl","#text":"str. 413-421"}],"dc:identifier":["ISSN:1318-0347","COBISSID:28448473","URN:URN:NBN:SI:doc-RIER6M8L"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"kronična mieloična levkemija"},{"@xml:lang":"sl","#text":"levkemija"},{"@xml:lang":"sl","#text":"neželeni učinki"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"zaviralci tirozinske kinaze"},{"@xml:lang":"sl","#text":"zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Resni neželeni učinki zdravljenja kronične levkemije z zaviralci tirozinske kinaze| case reports and literature review| prikaz primerov in pregled literature| Severe adverse effects associated with tyrosine kinase inhibitors therapy in chronic myeloid leukaemia|"},"dc:description":{"@xml:lang":"sl","#text":"Background: Chronic myeloid leukaemia is a clonal myeloproliferative disorder of myeloid progenitor cells. The availability of moleculartargeted therapy with tyrosine kinase inhibitors has changed the course and treatment for patients with chronic myeloid leukemia. The long-term follow-up of adverse events amongst the kinase inhibitors played role in forming decision- making algorithms for the use of this highly effective group of therapeutics. Patients and methods: In this paper, four CML patients are presented, treated with different tyrosine kinase inhibitors. Haematologic toxicity of kinase inhibitors is the most frequent adverse effect; however, non-haematological adverse effects should also not be neglected. Conclusions: Tyrosine kinase inhibitors have changed the therapy of CML, the treatment of these patients isa long-term process. Therefore, to know adverse effects is the matter of great importance in order to promptly recognise them and treat them properly"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-RIER6M8L","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-RIER6M8L"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-RIER6M8L/8158dc5a-5324-41b3-9e1b-450d527ff012/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-RIER6M8L/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-RIER6M8L"}}}}