38 KB480 KB29 KB192920262011Borinc Beden, AndrejaKreft, SamoPerko, JureTerčelj, Robertštevilka:4letnik:80str. 276-284ISSN:1318-0347COBISSID:3000433URN:URN:NBN:SI:doc-RJEPU8T2slSlovensko zdravniško društvoZdravniški vestnikbršljanchilddihalaotrocisirupitherapyvnetjazdravljenjePotek zdravljenja akutne okužbe dihal pri slovenskih otrocih s sirupom, ki vsebuje izvleček listov bršljana| Treatment of acute respiratory infections in Slovenian children with ivy leaf extract syrup|Background: The ivy leaf extract is a natural substance with secretolytic effect. Its efficacy and safety have been documented in several randomized, double-blind placebo-controlled trials. The aim of our study was to confirm the safety of ivy leaf extract in Slovenian children with acute inflammatory airway disease and to investigate the course of treatment. Methods: 193 children with clinical signs of acute airway disease, aged 2 to 14 years were included in a prospective postmarketing study. At the beginning of the study, 7-day treatment with syrup of ivy leaf extract was started. Results: The treatment was effective in 93.7 % of children, who showed an improvement of clinical symptoms. The proportion of children with productive cough was 43.6 %at first visit and 84.9 % at second visit. Skin allergy as a side effect was reported in one child. Conclusions: The study demonstrated that the treatment with ivy leaf extract is safe in children with acute inflammatory airway disease. The quality of sputum and frequency of cough changed during the treatment, and the majority of physicians and patients estimated that the treatment was more effective than in previous episodes of the disease when they had not received this drugIzhodišča: Izvleček listov bršljana je naravna zdravilna učinkovina s sekretolitičnim delovanjem. Njegovo učinkovitost in varnost so preverili v več randomiziranih, dvojno slepih s placebom kontroliranih raziskavah. Z našo raziskavo smo želeli potrditi varnost sirupa z izvlečkom listov bršljana pri slovenskih otrocih z akutno okužbo dihal, pri kateri je prisotno vnetje s povečano tvorbo izločkov v dihalnih poteh, ter ugotoviti potek zdravljenja. Metode: V prospektivno, neinterventno raziskavo smo vključili 193 otrok, starih od 2 do 14 let, ki so zboleli z znaki akutne okužbe dihal. Otroci so bili 7 dni zdravljeni s sirupom z izvlečkom listov bršljana, ki že ima dovoljenje za promet v R Sloveniji kot zdravilo (postmarketinška raziskava). Rezultati: Zdravljenje je bilo učinkovito pri 93,7 % otrok, pri katerih je prišlo do izboljšanja kliničnih simptomov. Delež otrok s produktivnim kašljem je bil pri prvem obisku znašal 43,6 %, pri drugem pa 84,9 %. Pri enem od otrok se je kot neželeni sopojav razvila koprivnica. Zaključki: Z raziskavo smo potrdili, da je zdravljenje s sirupom, ki vsebuje izvleček listov bršljana,pri otrocih z akutno okužbo dihal in s povečano tvorbo sluzi varno, med zdravljenjem pa se je spremenila kakovost izmečka, pogostost izkašljevanja in drugih simptomov akutne okužbe, kar so zdravniki in otroci oziroma njihovi starši ocenili kot učinkovito v primerjavi s predhodnimi znaki bolezni, ko sirupa niso prejemaliTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo