37 KB83 KB36 KB192920262004Kac, JavorMlinarič, Alešletnik:73številka:9str. 667-671ISSN:1318-0347COBISSID:1578865URN:URN:NBN:SI:doc-S6LG9PIEslSlovensko zdravniško društvoZdravniški vestnikdruginterakcijeučinkovinezdravilazdravilne rastlinePomembne interakcije nekaterih zdravilnih rastlin z zdravili| Important herb-drug interactions|Background. Herbal medicines have been popular for self-medication for a long time. Patients consider them to be safe because of their natural origin. Concurrent use of herbal medicines with other drugs can lead to interactions that are manifested as amplified or reduced pharmacological or toxic effect ofany of the pair. It is worrying that patients use herbal medicines with prescribed or OTC drugs without informing the physician. Conclusions. Many herbal medicines influence the action of numerous drugs. Medicinal plants mostoften involved in the interactions are St. Johnćs wort (Hypericum perforatum), garlic (Allium sativum), ginkgo (Ginkgo biloba), ginseng (Panax ginseng), kava (Piper methysticum), and grapefruit (Citrus paradisi). Dangerous interactions are more likely to occur in perioperative patients as they use many prescribed drugs at the same time. Also sensitive to interactions are transplant patients, patients on anticoagulants and HIV patients receiving antiretroviral therapy. Physicians should consider possibleinteractions with herbal medicines when prescribing drugs and before operations. Patients should be asked if they use any of the above listed herbs. Physicians should warn them about the dangers of simultaneous use of those herbs and prescribed or OTC drugsIzhodisea. Zdravilne rastline so ze od nekdaj zelo priljubljene za samozdravljenje, ker dajejo zaradi naravnega izvora uporabnikom obeutek varnosti. Pri soeasni uporabi zdravilnih rastlin in drugih zdravilnih ueinkovin pa lahko prihaja do interakcij. Tako lahko pride do poveeanega ali zmanjsanega farmakoloskega ali toksienega ueinka ueinkovin rastlinskega ali sinteznega izvora. Zaskrbljujoee je dejstvo, da bolniki uzivajo zdravila naravnega izvora skupaj z zdravili, predpisanimi na recept ali izdanimi brez recepta, o tem pa zdravnik ni obveseen. Zakljueki. Veliko zdravilnih rastlin vpliva na delovanje stevilnih zdravil. Zdravilne rastline, ki najpogosteje nastopajo v interakcijah z ostalimi zdravili, so sentjanzevka (Hypericum perforatum), eesen (Allium sativum), ginko (Ginkgo biloba), ginseng (Panax ginseng), kava kava (Piper methysticum) in grenivka (Citrus paradisi). Moznostzapletov je veeja pri bolnikih, ki eakajo na operacijo oziroma so jo prestali, saj ti obieajno prejemajo vee zdravil hkrati. Obeutljivi na interakcije so tudi bolniki po presaditvah organov, tisti, ki jemljejo antikoagulante, ter bolniki, ki prejemajo antiretrovirusne ueinkovine. Zdravniki bi zato pri predpisovanju zdravil in pred operacijo morali imeti v mislih tudi moznost interakcij z zdravilnimi rastlinami, ki jih bolniki po navadi jemljejo za samozdravljenje. Bolnike bi morali vprasati o jemanju v prispevku nastetih zdravilnih rastlin in jih opozarjati na nevarnosti soeasnega jemanja z zdravili, predpisanimi na recept ali izdanimi brez receptaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo