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I-201-I-205"}],"dc:identifier":["ISSN:1318-0347","COBISSID:3486015","URN:URN:NBN:SI:doc-SC19IH7M"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"breast"},{"@xml:lang":"en","#text":"Breast Neoplasms"},{"@xml:lang":"sl","#text":"Dojka, novotvorbe"},{"@xml:lang":"sl","#text":"dojke"},{"@xml:lang":"sl","#text":"Kakovost življenja"},{"@xml:lang":"sl","#text":"klimakterij"},{"@xml:lang":"en","#text":"Menopause"},{"@xml:lang":"sl","#text":"Menopavza"},{"@xml:lang":"en","#text":"Quality of Life"},{"@xml:lang":"sl","#text":"rak (medicina)"},{"@xml:lang":"en","#text":"standard of living"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"en","#text":"Vaginitis"},{"@xml:lang":"sl","#text":"Zdravljenje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Možnosti zdravljenja klimakteričnih težav pri bolnicah z rakom dojk| Treatment possibilities of menopausal symptoms in breast cancer patients|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Breast cancer is the most common cancer in women. Menopausal symptoms, which can highly reduce quality of life in women of all ages, are frequent side-effects of systemic treatment of early breast cancer whether treated by hormonal or cytotoxic therapy. Methods. The article presents literature review of the causes, assessment and management of menopausal syptoms in breast cancer patients. Results. There are a number of non-hormonal drugs effective in treating vasomotor symptoms, and some alternative therapies, such as black cohosh, phytoestrogens, homeopathy, acupuncture, yoga and behaviour strategies. The decision, whether and which pharmacologic or non-pharmacologic treatment to choose, depends on symptoms and on patient wishes. The most effective drugs for reducing hot flashes are vanlafaxine, paroxetine and gabapentin, unfortunately, the side effects are common. Vaginal estrogens are the most effective for treating atrophic vaginitis, but the safety in breast cancer patients is no established. Conclusions. Menopausal symptoms after breast cancer are severe and frequent and significantly reduce quality of life. Unfortunately, the possibility of treatment is limited"},{"@xml:lang":"sl","#text":"Izhodišča. Rak dojk je najpogostejši rak pri ženskah. Klimakterične težave, ki zelo poslabšajo kakovost življenja pri ženskah vseh starosti, so pogost sopojav sistemskega zdravljenja, tako hormonskega zdravljenja kot zdravljenja s citostatiki. Metode. V prispevku je predstavljen pregled literature o vzrokih, načinu obravnave in možnostih zdravljenja klimakteričnih težav pri bolnicah z rakom dojk. Rezultati. Za lajšanje vazomotornih simptomov obstaja več vrst nehormonskih zdravil in nekaj alternativnih zdravljenj, na primer z rastlino cimicifugo, fitoestrogeni, homeopatijo, akupunkturo, jogo in spremembo načina življenja. Za kakšno vrsto farmakološkega ali nefarmakološkega zdravljenja se bomo odločili, zavisi od vrste težav ter želja bolnice. Najbolj učinkovita zdravila za zmanjšanje vročinskih oblivov so venlafaksin, paroksetin in gabapentin, žal pa so sopojavi pogosti. Za lajšanje težav zaradi atrofičnega kolpitisa so najbolj učinkoviti lokalno aplicirani estrogeni, vendar varnost pri bolnicah z rakom dojk ni povsem dognana. Zaključki. Klimakterične težave pri bolnicah z rakom dojk so pogost in resen problem, ki bistveno vpliva na kakovost življenja. Možnosti zdravljenja so na žalost precej omejene"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-SC19IH7M","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-SC19IH7M"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-SC19IH7M/0902fc60-f564-4df0-ac79-50513f552395/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-SC19IH7M/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-SC19IH7M"}}}}