<?xml version="1.0"?><rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:edm="http://www.europeana.eu/schemas/edm/" xmlns:wgs84_pos="http://www.w3.org/2003/01/geo/wgs84_pos" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:rdaGr2="http://rdvocab.info/ElementsGr2" xmlns:oai="http://www.openarchives.org/OAI/2.0/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:ore="http://www.openarchives.org/ore/terms/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:dcterms="http://purl.org/dc/terms/"><edm:WebResource rdf:about="http://www.dlib.si/stream/URN:NBN:SI:doc-SC3CBJXG/5ac5cfe9-2810-4035-be18-3d4b32dc821b/PDF"><dcterms:extent>287 KB</dcterms:extent></edm:WebResource><edm:WebResource rdf:about="http://www.dlib.si/stream/URN:NBN:SI:doc-SC3CBJXG/3add7e13-6956-4a81-b7b3-faf670447d32/TEXT"><dcterms:extent>15 KB</dcterms:extent></edm:WebResource><edm:TimeSpan rdf:about="1992-2025"><edm:begin xml:lang="en">1992</edm:begin><edm:end xml:lang="en">2025</edm:end></edm:TimeSpan><edm:ProvidedCHO rdf:about="URN:NBN:SI:doc-SC3CBJXG"><edm:isNextInSequence rdf:resource="https://www.dlib.si/details/URN:NBN:SI:doc-XUGUZSLP" /><dcterms:isPartOf rdf:resource="https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S" /><dcterms:issued>1999</dcterms:issued><dc:creator>Arnež, Zoran M.</dc:creator><dc:creator>Planinšek, Franc</dc:creator><dc:format xml:lang="sl">letnik:33</dc:format><dc:format xml:lang="sl">str. S40-S44</dc:format><dc:format xml:lang="sl">številka:suppl. 1</dc:format><dc:identifier>COBISSID:10733529</dc:identifier><dc:identifier>ISSN:1318-2099</dc:identifier><dc:identifier>URN:URN:NBN:SI:doc-SC3CBJXG</dc:identifier><dc:language>sl</dc:language><dc:publisher xml:lang="sl">Croatian Medical Association - Croatian Society of Radiology</dc:publisher><dc:publisher xml:lang="sl">Slovenian Medical Society - Section of Radiology</dc:publisher><dcterms:isPartOf xml:lang="sl">Radiology and oncology (Ljubljana)</dcterms:isPartOf><dc:subject xml:lang="sl">dermatologija</dc:subject><dc:subject xml:lang="sl">kirurško zdravljenje</dc:subject><dc:subject xml:lang="sl">Lymph node excision</dc:subject><dc:subject xml:lang="sl">melanom</dc:subject><dc:subject xml:lang="sl">Melanoma</dc:subject><dc:subject xml:lang="sl">Skin neoplasms</dc:subject><dc:subject xml:lang="sl">Surgery</dc:subject><dcterms:temporal rdf:resource="1992-2025" /><dc:title xml:lang="sl">Kirurško zdravljenje malignega melanoma| Surgical treatment of malignant melanoma|</dc:title><dc:description xml:lang="sl">Although the incidence and the mortality rates of malignant melanoma (MM) havebeen increasing worldwide and in Slovenija for the last several decades, the survival rates are improving. The apparent contradiction may be expained by the increase in early diagnnosis of MM. If detected early in its clinical course MM can be cured by a simple surgical excision in majority of patients. The decision about the margins of the surgical excision of the primary melanoma site has been made more rational through correlations of rates of local control with different margins of resection in relation to the domianantprognostic factor for localized melanoma, the thickness of the lesion. When possible, primary closure of the post-excisional defect should beperformed. If primary closure is impossible, the wound may be closed by split or full thickness skin grafting, local, regional or free flaps. Electivedissection has not been shown in prospective randomized trials to alter survival significantly. Surgical treatment of distant metastases is indicated only as palliation of a solitary symptomatic lesion (brain metastases, lung or gastrointestinal metastases)</dc:description><dc:description xml:lang="sl">Incidenca in umrljivost zaradi malignega melanoma (MM) rasteta v svetu in pri nas. Kljub temu je prognoza bolezni danes boljša zaradi zgodnejšega odkrivanjaMM. MM je v zgodnjem kliničnem obdobju ozdravljiv s preprostim kirurškim izrezom sumljivo spremenjenega tkiva z varnostnim robom. Primerjava debeline tumorja in uspešnosti lokalnega nadzora bolezni ob izrezih različno širokega varnostnega pasu je zožila varnostni pas iz prejšnjih 5 in več cm ("široka ali razširjena ekscizija") na 1 do 2 cm. Zato lahko danes pri večini bolnikov z malignim melanomom zapremo nastalo tkivno vrzel po odstranitvi tumorja zgolj z neposrednim šivom rane, le redko pa s prostimi kožnimi presadki in lokalnimi, oddaljenimi ali prostimi režnji. Izbirna (elektivna) odstranitev področnih bezgavk ni smiselna. Za terapevtsko odstranitev področnih bezgavk se odločimo pri pozitivni varovalni bezgavki oz. pri na otippovečanih regionalnih bezgavkah brez znakov sistemskega razsoja. Osamljene(solitarne) oddaljene zasevke odstranimo izjemoma in le v tistih primerih, ko postanejo simptomatski. (npr.zvišan intrakranialni tlak, mehanskaovira v prehodnosti cevastih organov, motnje dihanja, pojav zlatenice)</dc:description><edm:type>TEXT</edm:type><dc:type xml:lang="sl">znanstveno časopisje</dc:type><dc:type xml:lang="en">journals</dc:type><dc:type rdf:resource="http://www.wikidata.org/entity/Q361785" /></edm:ProvidedCHO><ore:Aggregation rdf:about="http://www.dlib.si/?URN=URN:NBN:SI:doc-SC3CBJXG"><edm:aggregatedCHO rdf:resource="URN:NBN:SI:doc-SC3CBJXG" /><edm:isShownBy rdf:resource="http://www.dlib.si/stream/URN:NBN:SI:doc-SC3CBJXG/5ac5cfe9-2810-4035-be18-3d4b32dc821b/PDF" /><edm:rights rdf:resource="http://rightsstatements.org/vocab/InC/1.0/" /><edm:provider>Slovenian National E-content Aggregator</edm:provider><edm:intermediateProvider xml:lang="en">National and University Library of Slovenia</edm:intermediateProvider><edm:dataProvider xml:lang="sl">Onkološki inštitut Ljubljana</edm:dataProvider><edm:object rdf:resource="http://www.dlib.si/streamdb/URN:NBN:SI:doc-SC3CBJXG/maxi/edm" /><edm:isShownAt rdf:resource="http://www.dlib.si/details/URN:NBN:SI:doc-SC3CBJXG" /></ore:Aggregation></rdf:RDF>