28 KB285 KB25 KB192920262006Kac, JavorKlančar, UrošKrbavčič, AlešMlinarič, Alešštevilka:3letnik:75str. 157-162ISSN:1318-0347COBISSID:1925233URN:URN:NBN:SI:doc-TDIYTIHLslSlovensko zdravniško društvoZdravniški vestnikalkaloidiatropinatropinerastlinerazhudnikovkeskopolaminstrupene rastlineVsebnosti atropina in skopolamina v strupenih rastlinah razhudnikovk na slovenskem| Content of atropine and scopolamine in poisonous Solanaceae plants from Slovenia|Some species from the Solanaceae family are still the cause of serious poisoning among youth in Slovenia. Usually intoxication is due to abuse of these plants to provoke hallucinations. There is still not enough data about the alkaloid content of these plants growing in Slovenia.Different plant samples were analyzed for the content of atropine and scopolamine with capillary electrophoresis after solid phase extraction of alkaloids. Plants were gathered from different areas of Slovenia between April and September 2004. Results Results were compared and possible correlations between the alkaloid content and species, plant parts, growth conditions, and time of harvest were suggested. Atropine and scopolamine contents were assessed in deadly nightshade (Atropa belladonna L.), thorn apple (Datura stramonium L.), scopolia (Scopolia carniolica Jacq.) and angel trumpet. The common name angel trumpet is used for Datura inoxia Mill. as well as for different Brugmansia Pers. species. The most intriguing results were the variable alkaloid content in various Brugmansia species and generally great differences in alkaloid content among various plants and their plant parts.All investigated plants have noticeable atropine andžor scopolamine content. The content is variable between various plants and their plant parts and therefore special care should be taken in cases of possible intoxication. It was shown that smaller or greater amounts of ingested drug can cause the same level of intoxication due to the variability in alkaloid contentNa Slovenskem so nekatere vrste iz druzine razhudnikovk se vedno pogost predmet resnih, v glavnem namernih zastrupitev. Zlorabe so v veeini med mladimi, ki zelijo doseei halucinogene ueinke po zauzitju teh rastlin. Kljub temu ne zasledimo dovolj podatkov v literaturi, ki bi prikazovali vsebnosti alkaloidov v teh strupenih vrstah na podroeju Slovenije.Kvantitativno smo doloeili vsebnost atropina in skopolamina v razlienih vrstah in rastlinskih delih razhudnikovk (Solanaceae), nabranih na podroeju Slovenije, v obdobju od aprila do septembra 2004. Vzorce smo po ekstrakciji trdnožtekoee analizirali spomoejo kapilarne elektroforeze.Dobljene rezultate smo med seboj primerjali ter iskali morebitne povezave med vsebnostjo alkaloidov in posameznimi vrstami, rastlinskimi deli, pogoji rasti in easom nabiranja. Vsebnost alkaloidov smo doloeili v posameznih drogah, pridobljenih iz rastlin voleje eesnje (Atropa belladonna L.), navadnega kristavca (Datura stramonium L.), kranjske bunike (Scopolia carniolica Jacq.), vrste Datura inoxia Mill. in razlienih vrst brugmanzij (Brugmansia spp. Pers.). Zadnji dve se pojavljata z bolj znanim skupnim imenom Ćangelska trobentaĆ. Vee pozornosti so nam vzbudilipredvsem rezultati o vsebnostih tropanskih alkaloidov vrste brugmanzijin na splosno velike razlike v vsebnostih alkaloidov med posameznimirastlinami in njihovimi rastlinskimi deli. Vse preiskovane rastlinevsebujejo znatne kolieine atropina inžali skopolamina. Vsebnosti med razlienimi rastlinami in njihovimi rastlinskimi deli nihajo in zahtevajo posebno pozornost pri sumu na morebitne zastrupitve. Manjsa ali veeja kolieinazauzite droge lahko zaradi razlik v vsebnosti povzroeita enako moeno zastrupitevTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo