24 KB70 KB18 KB199220252009Botros, MaikelMiller, Robert C.Quevedo, J. Fernandoštevilka:2letnik:43str. 126-131ISSN:1318-2099COBISSID:25672921URN:URN:NBN:SI:doc-TWG1A7GDenAssociation of Radiology and OncologyRadiology and oncology (Ljubljana)Adverse EffectsangiosarkomCombined Modality TherapyGallbladder NeoplasmsHemangiosarcomaHemangiosarkomJetra, novotvorbeKombinirani način zdravljenjaLiver NeoplasmsMiddle Ageradioterapijarak (medicina)Srednja letaTherapyžolčnikŽolčnik, novotvorbeAngiosarcoma of the liver after multimodality therapy for gallbladder carcinoma|Background. Treatment-induced angiosarcoma is a rare complication of cancer therapy and is best known for arising on the chest wall after a mastectomy. Wereport an unusual case of a treatment-induced angiosarcoma developing in theliver after adjuvant radiotherapy for gallbladder carcinoma. Case report. Radiation-induced angiosarcoma of the liver developed in a 46-year-old woman after radiotherapy for stage IIB (T3N1M0) adenocarcinoma of the gallbladder in1991. The patient subsequently underwent resection, postoperative external beam radiotherapy, and multiagent chemotherapy. Several severe late adverse effects developed, including duodenal obstruction with fistula formation and chronic mesenteric ischemia secondary to occlusion of the superior mesenteric artery. Six years after her gallbladder resection and adjuvant treatment, a fatal grade 4 of 4 angiosarcoma of the liver developed within the radiation field. Conclusions. To our knowledge, this is the first case of radiation-induced angiosarcoma of the liver after radiotherapy for gallbladdercarcinoma. Normal organ dose-volume limits should be considered carefully when delivering a course of external beam radiotherapy in the upper abdomenTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo radiologije in onkologije