38 KB612 KB36 KB192920262011Erman, Andrejaštevilka:6letnik:80str. 489-498ISSN:1318-0347COBISSID:28578009URN:URN:NBN:SI:doc-VAJKM98WslSlovensko zdravniško društvoZdravniški vestnikdrugfarmacijahitinhitosanpharmacypolimerivnos učinkovinzdravilaHitosan in možna uporaba v medicini| Chitosan and its possible use in medicine|Background: Searching for new drug formulations, which enable drug targeting to specific tissues and cells, is in full swing. Various investigations of polymers including chitosan indicate a wide applicability in the pharmaceutical field and consequently also in medicine due to its established physicochemical properties. Chitosan is a natural polymer obtained by deacetylation of chitin. Cationic nature and conformation permit chitosan to react with anionic drugs and to be a promising bioadhesive material. All this gives chitosan a potential to be a controlled delivery system for drug targeting . Conclusions: In in vitro investigations, chitosan has proved to bea succesful, safe and non-toxic drug delivery system. These results are confirmed also by recent in vivo investigations. This implies that chitosan has wide possibilities in the treatment of some urgent medical problems, such as atherosclerosis, allergies and gastric ulcers. Its succesful and safe applicability render chitosan potentially useful in the treatment of bacterialinfections, in tissue engineering, immunoprophylaxis and in gene therapyTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo