22 KB77 KB21 KB199220252002Anderluh, Francštevilka:1letnik:366 stranistr. 41-46ISSN:1318-2099COBISSID:14747865URN:URN:NBN:SI:doc-WG46L3LMenAssociation of Radiology and OncologyRadiology and oncology (Ljubljana)BiopsijaBiopsyDiagnosisdiagnostikaLimfangiomiomatozalimfni sistemLymphangiomyomatosisPathologypljučaTherapyTomografija radiografska, računalniškaTomography, X-ray computedLymphangioleiomyomatosis|Background. Lymphangioleiomyomatosis is a rare disease of unknown origin, which affects women in their reproductive period. It is characterised by non-neoplastic proliferation of atypical smooth muscle cells in the lung parenchyma, lymphatic vessels and mediastinal and abdominal lymph nodes. The most common presenting symptoms are spontaneous pneumothorax, dyspnea, hemoptysis and chylothorax. Conclusions. High-resolution computed tomography (HRCT) and open lung biopsy followed by the immunohistologic studies are two diagnostic procedures with which diagnosis can be confirmed. Various treatmentmodalities are applied, particularly hormonal therapy, though their efficacy remain unknown. The prognosis of patients is badlzhodišča. Limfangioleiomiomatoza je redka bolezen neznanega vzroka, za katerozbolevajo ženske v rodnem obdobju. Za bolezen je značilna neneoplastičnaproliferacija atipičnih gladkomišičnih celic v pljučnem parenhimu, limfnih žilah ter mediastinalnih in abdominalnih bezgavkah. V klinični sliki se pojavljajo spontani pnevmotoraksi, dispneja, hemoptize in hilotoraks. Zaključlti. Računalniška tomografija visoke ločljivosti in imunohistološke metode v bioptičnih vzorcih pljučnega tkiva nam omogočajo pravilno postavitev diagnoze. Načini zdravljenja so različni, običajno hormonski, vendar je zaenkrat njihov uspeh še vprašljiv, prognoza bolnikov pa slabaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo radiologije in onkologije