{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-XCLHZNQI/cb72c238-a452-4cbd-bb34-17aa04684c58/PDF","dcterms:extent":"340 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-XCLHZNQI/de51fdd6-9f43-4d5d-b926-d7b1506a4141/TEXT","dcterms:extent":"64 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-XCLHZNQI","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2024","dc:creator":["Bajt, Aleksandra","Bricl, Irena","Marić, Ivica"],"dc:contributor":"Bajt, Aleksandra","dc:format":[{"@xml:lang":"sl","#text":"številka:11/12"},{"@xml:lang":"sl","#text":"letnik:93"},{"@xml:lang":"sl","#text":"str. 387-399"}],"dc:identifier":["DOI:10.6016/ZdravVestn.3491","ISSN:1318-0347","COBISSID:221278723","URN:URN:NBN:SI:doc-XCLHZNQI"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"hemovigilanca"},{"@xml:lang":"sl","#text":"krvne komponente"},{"@xml:lang":"sl","#text":"pljučni edem"},{"@xml:lang":"sl","#text":"respiracijska transfuzijska reakcija"},{"@xml:lang":"sl","#text":"srčno popuščanje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"S transfuzijo povezana volumska preobremenitev| Transfusion-associated circulatory overload (TACO)|"},"dc:description":[{"@xml:lang":"sl","#text":"Transfusion-associated circulatory overload (TACO) is the most common respiratory adverse transfusion reaction (ATR). TACO is defined as acute or worsening respiratory compromise and/or acute or worsening pulmonary oedema during or up to 12 hours of transfusion, with additional features including cardiovascular system changes not explained by the patient’s underlying medical condition, evidence of fluid overload, and a relevant biomarker. TACO is caused by a volume overload in predisposed individuals, such as patients with heart failure, the elderly, infants, patients with severe anaemia, and patients with positive fluid balance. On the other hand, suboptimal fluid management (e.g., a rapid transfusion of a large volume of blood product) or other components in the transfused product may enable the second hit in the two-hit TACO pathophysiology model. TACO treatment should include immediate cessation of the transfusion, placing the patient in an upright position, administering oxygen, diuretics, and other pulmonary oedema therapy. Mechanical ventilation and treatment in the intensive care unit may be required. Although TACO is the foremost cause of transfusion-related morbidity and mortality in countries with well-developed transfusion services in recent years, it has been historically both underrecognized and underreported. It remains very challenging to distinguish it from underlying causes of lung injury and/or fluid overload as well as from the other two respiratory ATRs: transfusion-related acute lung injury (TRALI), and transfusion-associated dyspnoea (TAD). This review article describes TACO, its 2018 ISBT/IHN/AABB definition, pathophysiology, clinical presentation, prevention, and treatment strategies, including a comparison table of all three primary respiratory ATR characteristics. TACO is a potentially fatal adverse complication of blood transfusion, and developing a thorough clinical understanding can improve haemovigilance reporting and can contribute to risk factor identification and preventative measures"},{"@xml:lang":"sl","#text":"S transfuzijo povezana volumska preobremenitev oz. TACO je najpogostejša respiracijska neželena transfuzijska reakcija (NTR). Pri TACO se med transfuzijo ali v 12 urah po njej pri dovzetnih bolnikih razvijeta kardiogeni pljučni edem in dihalna stiska zaradi volumske preobremenitve s tekočinami. Ogroženi so novorojenčki in dojenčki, starostniki, bolniki s srčnim popuščanjem, bolniki s hudo anemijo ter bolniki s pozitivno tekočinsko bilanco. Tvegana sta hitra transfuzija in večji vo-lumen transfundiranih krvnih komponent. Bolnike s TACO zdravimo z dodajanjem kisika, intravenskimi diuretiki, nitrati in morfinskimi pripravki ter po potrebi z neinvazivnim ali invazivnim mehanskim predihavanjem. Čeprav je TACO v zadnjih le-tih v razvitem svetu najpogostejši vzrok za zbolevnost in za smrtni izid transfuzije, se ga pogosto spregleda in zato ne prijavi hemovigilančni službi. K temu prispevajo tako pomanjkljivo (pre)poznavanje simptomov in znakov TACO ter prekrivanje kliničnih slik pri kritično bolnih, kot tudi zahtevno razlikovanje od drugih dveh primarnih respiracijskih NTR: s transfuzijo povezane akutne okvare pljuč oz. TRALI in s transfuzijo povezane dispneje oz. TAD. S pregledom svetovne literature smo v članku povzeli najnovejša dognanja o patofiziologiji, klinični sliki in zdravljenju ter preprečevanju TACO. Podrobno opisu-jemo ISBT/IHN/AABB definicijo TACO iz leta 2018. Posebno pozornost smo namenili prikazu razlik med TACO, TRALI in TAD, ki bodo zdravnikom v pomoč pri diagnosticiranju. Za preprečevanje hudih posledic pri bolnikih je nujno potrebno znanje o preprečevanju, prepoznavanju in zdravljenju respiracijskih NTR. Enako velja za prijavljanje NTR hemovigilančni službi"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-XCLHZNQI","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-XCLHZNQI"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-XCLHZNQI/cb72c238-a452-4cbd-bb34-17aa04684c58/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-XCLHZNQI/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-XCLHZNQI"}}}}