20 KB1946 KB15 KB199220252008Aberer, W.Kränke, BirgerMayr-Kanhäuser, Sigridletnik:17številka:3str. 139-143ISSN:1318-4458COBISSID:24955097URN:URN:NBN:SI:doc-XMZIIXEEenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaAcne VulgarisAdministration, TopicalAkna navadnaakneantibioticantibiotikiAnti-Infective Agents, LocalAntiinfektivi lokalniDrug TherapyrezistencatherapyZdravilo, lokalna uporabazdravljenjeEfficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne|Background: With the increase in antibiotic-resistant strains of microorganisms in acne lesions, the search for alternative treatment methods has become important. We studied the efficacy of a combination of the antiseptic substances octenidine dihydrochloride and 2-phenoxyethanol (O/P) in mild to moderate inflammatory acne vulgaris. Methods: Thirty patients were instructed to apply O/P once or twice daily for a 6-week treatment period. Determination of efficacy included the numerical documentation of inflammatoryand non-inflammatory lesions within defined regions of the face bythe investigator, and photodocumentation of the clinical picture as well as the fluorescence pattern under Wood's light. Results: Twenty-four patients completed the study. The number of papules and pustules decreased more than 50% in seventeen and nineteen patients, respectively. Acne lesions worsened inonly one patient. Mild adverse reactions (erythema, burning, and scaling) were seen in two patients. Therefore, O/P was highly effective in treating inflammatory lesions of facial acne, but there was no essential efficacy in the non-inflammatory primary acne lesions. Conclusion: Topical O/P is a good and cost-effective alternative in the treatment of mild to moderate inflammatory acne lesions and may allow reduced application of anti-acne antibiotics to prevent development of resistanceTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov