16 KB71 KB14 KB199220252005Homma, ShinsukeIshikawa, HiroichiKagohashi, KatsunoriKurishima, KoichiOhtsuka, MorioSatoh, HiroakiSekizawa, Kiyohisaštevilka:1letnik:395 stranistr. 49-53ISSN:1318-2099COBISSID:19321305URN:URN:NBN:SI:doc-ZB2STDC0enAssociation of Radiology and OncologyRadiology and oncology (Ljubljana)Lung NeoplasmsNeoplasms, Multiple PrimarynovotvorbeNovotvorbe multiple primarnePljučne novotvorbepljučni rakPrognosisPrognozatumorMultiple primary malignancies in patients with lung cancer|Background. To evaluate the incidence of multiple prirnary malignancies in lung cancer patient`s, we summarized our experience in lung cancer patients with multiple primary malignancies. Methods. A total of 1194 consecutive Lung cancer patients, who were admitted to our division over a 29 year period up toAugust 2004, were retrospectively analyzed. Results. Ninety-eight (8.2`) of 1194 lung cancer patients had multipte prirnary malignancies. Metachronous malignant disease comprised 77.6% and synchronous 21.4%. Multiple primary tumours in our patients were detected rnore frequent in the advanced stage of lung cancer (IIIA-IV 67.3%) than in the early stage (IA-IIB 32.7%). The histological examination of lung cancer revealed a preponderance of squamous cell carcinoma (40 patients, 40.8%). First primary tumours developed most commonly in gastrointestinal tract, fallowed by lung and uterus. Fifty-seven (85.1%) of 67 patients with aerogastrointestinal and head and neck cancers hada smoking habit. In 98 patients with multiple primary cancers, forty (40.8%) patients had stage IA-IIIA lung cancer, however, 26 (26.5%) had a surgical resection. Conclusions. Existing metachronous primary tumours proved to be a worse prognostic factor in non-small cell lung cancer patients (p=0.0480), while synchronous primary turnours were not, as well as there was not proven that multiple primary tumours were worse prognostic factors in patients with small cell lung cancerIzhodišča. Da bi ugotovili incidenco in vrsto multiplih primarnih malignomov pri bolnikih s pljučnim rakom, smo naredili retrospektivno raziskavo. Metode. Analizirali smo podatke o 1194 bolnikih s pljučnim rakom, ki smo jih na našem oddelku obravnavali v 29-letnem obdobju do avgusta 2004. Rezultati. Ugotovili smo, da je 98 (8,2%) od 1194 bolnikov s pljučnim rakom imelo multipli primarnimalignom. Metahrono so bili odkriti v 77,6% , sinhrono pa v 21,4%. Bolj pogosto so nastajali pri napredovalih oblikah pljučnega raka (v stadijih IIIA do IV 67,3%) kot pa v zgodnji oblikah (v stadijih IA do IIB 32,7%). Najpogostejši je bil skvamoznocelični karcinom (pri 40 bolnikih oz. pri 40,8%). Najpogostejši prvi primarni tumor smo našli v gastrointestinalnem traktu, nato v pljučih in maternici. 57 (85,1%) od 67 bolnikov, ki je imelo malignom v prebavilih, dihalih ter glavi in vratu, je bilo kadilcev. Od 98 bolnikov, ki so imeli multipli primarni malignom, jih je bilo kirurško zdravljenih le 26 (26,5%), čeprav jih je 40 (40,8%) imelo omejeno obliko pljučnega raka s stadijem IA-IIIA. Zaključki. Ugotovili smo, da pri bolnikih znedrobnoceličnim pljučnim rakom predstavlja metahroni multipli primarni malignom statistično značilen napovedni dejavnik (p=0,0480), kar pa nismo uspeli potrditi pri bolnikih z drobnoceličnim pljučnim rakom in pri sinhronih malignomihTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo radiologije in onkologije